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Publications of Interest

Additional Publications (130)

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q 2016 Reprogrammed Stomach Tissue as a Renewable Source of Functional beta Cells for Blood Glucose Regulation. Cell Stem Cell 2016 Mar 3;18(3):410-21. Epub 2016 Feb 18. [PubMed Abstract]

Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC 2016 Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut. 2016 Mar 1. [PubMed Abstract]

Kim TH, Shivdasani RA 2016 Stomach development, stem cells and disease. Development (Cambridge, England) 2016 Feb 15;143(4):554-65. [PubMed Abstract]

Cantrell MA, Kuo CJ 2015 Organoid modeling for cancer precision medicine. Genome medicine 7:32 [PubMed Abstract]

Chang P, Qu Y, Liu Y, Cui S, Zhu D, Wang H, Jin X 2013 Multi-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury. Cell death & disease 4:e685 [PubMed Abstract]

*Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinje J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM 2015 Serological Correlates of Protection against a GII.4 Norovirus. Clinical and vaccine immunology : CVI [PubMed Abstract]

Finkbeiner SR, Freeman JJ, Wieck MM, El-Nachef W, Altheim CH, Tsai YH, Huang S, Dyal R, White ES, Grikscheit TC, Teitelbaum DH, Spence JR 2015 Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids. Biology Open.2015Oct12;. [PubMed Abstract]

Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L 2015 Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol.2015 Oct22;:ajpgi 00244.2015 [PubMed Abstract]

*Jayewickreme CD, Shivdasani RA 2015 Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Developmental biology [PubMed Abstract]

San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA 2015 Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports.2015Oct13;. [PubMed Abstract]

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar U, Sastri NP, Conner ME, Opekun A, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK 2015 Human Intestinal Enteroids: A New Model to Study Human Rotavirus Infection, Host Restriction and Pathophysiology. J Virol.2015Oct7;. [PubMed Abstract]

*Shi Z, Chiang CI, Labhart P, Zhao Y, Yang J, Mistretta TA, Henning SJ, Maity SN, Mori-Akiyama Y 2015 Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. Nucleic acids research [PubMed Abstract]

Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA 2015 SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cellular and molecular gastroenterology and hepatology 2015 Nov 1;1(6):598-609. e6. [PubMed Abstract]

Sureban SM, Qu D, Houchen CW 2015 Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. Current pharmacology reports 2015Aug1;1(4):217-222 [PubMed Abstract]

Yusung SA, Martin MG 2015 A Breath of Fresh AIRE Surrounds Paneth Cells and Defensins. Gastroenterology 149:22-25 [PubMed Abstract]
Barker N 2014 Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nature reviews Molecular cell biology 15:19-33 [PubMed Abstract]

Chang P, Qu Y, Liu Y, Cui S, Zhu D, Wang H, Jin X 2013 Multi-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury. Cell death & disease 4:e685 [PubMed Abstract]

*Kinzel B, Pikiolek M, Orsini V, Sprunger J, Isken A, Zietzling S, Desplanches M, Dubost V, Breustedt D, Valdez R, Liu D, Theil D, Muller M, Dietrich B, Bouwmeester T, Ruffner H, Tchorz J 2014 Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Developmental biology [PubMed Abstract]

Kovalenko PL, Basson MD 2013 The correlation between the expression of differentiation markers in rat small intestinal mucosa and the transcript levels of schlafen 3. JAMA surgery 148:1013-1019 [PubMed Abstract]

Ong BA, Vega KJ, Houchen CW 2014 Intestinal stem cells and the colorectal cancer microenvironment. World journal of gastroenterology : WJG 20:1898-1909 [PubMed Abstract]

Ritsma L, Ellenbroek SI, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature. 2014;507(7492):362-365. [PubMed Abstract]
Akcora D, Huynh D, Lightowler S, Germann M, Robine S, de May JR, Pollard JW, Stanley ER, Malaterre J, Ramsay RG 2013 The CSF-1 receptor fashions the intestinal stem cell niche. Stem cell research 10:203-212 [PubMed Abstract]

Aust G, Kerner C, Gonsior S, Sittig D, Schneider H, Buske P, Scholz M, Dietrich N, Oldenburg S, Karpus ON, Galle J, Amasheh S, Hamann J 2013 Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Molecular biology of the cell 24:2256-2268 [PubMed Abstract]

Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ 2013 Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495:65-69 [PubMed Abstract]

Castellanos-Gonzalez A, Cabada MM, Nichols J, Gomez G, White AC, Jr. Human primary intestinal epithelial cells as an improved in vitro model for Cryptosporidium parvum infection. Infection and immunity. Jun 2013;81(6):1996-2001. [PubMed Abstract]

Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V 2013 Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology 144:381-391 [PubMed Abstract]

Folgueras AR, Guo X, Pasolli HA, Stokes N, Polak L, Zheng D, Fuchs E 2013 Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function. Cell stem cell 13:314-327 [PubMed Abstract]

Gemei M, Mirabelli P, Di Noto R, et al. CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo. Cancer. Feb 15 2013;119(4):729-738. [PubMed Abstract]

King SL, Dekaney CM 2013 Small intestinal stem cells. Current opinion in gastroenterology 29:140-145. [PubMed Abstract]

*King SL, Mohiuddin JJ, Dekaney CM. Paneth Cells Expand from Newly Created and Pre-existing Cells During Repair After Doxorubicin-Induced Damage. Am J Physiol Gastrointest Liver Physiol. May 9 2013. [PubMed Abstract]

Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP 2013 A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut 62:83-93. [PubMed Abstract]

Parry L, Young M, El Marjou F, Clarke AR: Evidence for A Crucial Role of Paneth Cells in Mediating the Intestinal Response to Injury. Stem Cells 2013. [PubMed Abstract]

Silk AD, Gast CE, Davies PS, Fakhari FD, Vanderbeek GE, Mori M, Wong MH 2013 Fusion between hematopoietic and epithelial cells in adult human intestine. PLoS One 8:e55572. [PubMed Abstract]

Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG, Houchen CW 2013 DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer. PLoS One 8:e73940 [PubMed Abstract]

Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem cells. 2013;31(5):992-1000. [PubMed Abstract]
Boni L, Chalajour F, Sasaki T, Snyder RL, Boyd WD, Riemer RK, Reddy VM: Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential. J Thorac Cardiovasc Surg 2012, 144:963-969 e961; discussion 969. [PubMed Abstract]

Chen, C. L.; Yu, X.; James, I. O.; Zhang, H. Y.; Yang, J.; Radulescu, A.; Zhou, Y.; Besner, G. E. Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis. Lab Invest 92(3):331-344; 2012. [PubMed Abstract]

Cordero, J. B.; Sansom, O. J. Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiol (Oxf) 204(1):137-143; 2012. [PubMed Abstract]

Davidson LA, Goldsby JS, Callaway ES, Shah MS, Barker N, Chapkin RS: Alteration of colonic stem cell gene signatures during the regenerative response to injury. Biochim Biophys Acta 2012, 1822:1600-1607. [PubMed Abstract]

de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, et al: Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol 2012, 32:3639-3647. [PubMed Abstract]

Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M: Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer 2012, 131:2242-2252. [PubMed Abstract]

Fatima, S.; Zhou, S.; Sorrentino, B. P. Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model. Stem Cells 30(2):210-221; 2012. [PubMed Abstract]

Fox RG, Magness ST, Kujoth GC, Prolla TA, Maeda N. MITOCHONDRIAL DNA POLYMERASE EDITING MUTATION, POLGD257A, DISTURBS STEM-PROGENITOR CELL CYCLING IN THE SMALL INTESTINE AND RESTRICTS EXCESS FAT ABSORPTION. Am J Physiol Gastrointest Liver Physiol 2012. [PubMed Abstract]

Fujii Y, Yoshihashi K, Suzuki H, Tsutsumi S, Mutoh H, Maeda S, Yamagata Y, Seto Y, Aburatani H, Hatakeyama M 2012 CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci U S A 109:20584-20589. [PubMed Abstract]

Gracz, A. D.; Puthoff, B. J.; Magness, S. T. Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine. Methods Mol Biol 879:89-107; 2012. [PubMed Abstract]

Hessman CJ, Bubbers EJ, Billingsley KG, Herzig DO, Wong MH. Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer. Am J Surg 2012. [PubMed Abstract]

Kalabis J, Wong GS, Vega ME, Natsuizaka M, Robertson ES, Herlyn M, Nakagawa H, Rustgi AK. Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture. Nat Protoc 2012;7(2):235-46. [PubMed Abstract]

Kim, T. H.; Escudero, S.; Shivdasani, R. A. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A 109(10):3932-3937; 2012. [PubMed Abstract]

Kushner JA. Development. Esophageal stem cells, where art thou? Science 2012;337(6098):1051-2. [PubMed Abstract]

Lund PK. Fixing the breaks in intestinal stem cells after radiation: a matter of DNA damage and death or DNA repair and regeneration. Gastroenterology 2012;143(5):1144-7. [PubMed Abstract]

Martinez Rodriguez NR, Eloi MD, Huynh A, Dominguez T, Lam AH, Carcamo-Molina D, Naser Z, Desharnais R, Salzman NH, Porter E. Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. Infect Immun 2012;80(1):266-75. [PubMed Abstract]

Morris JF, Sul JY, Kim MS, Klein-Szanto AJ, Schochet T, Rustgi A, Eberwine JH. Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Hum Pathol 2012. [PubMed Abstract]

Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, Chiba T. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 2012. [PubMed Abstract]

Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, et al: Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem 2012, 287:37296-37308. [PubMed Abstract]

Pierzchalska M, Grabacka M, Michalik M, Zyla K, Pierzchalski P. Prostaglandin E2 supports growth of chicken embryo intestinal organoids in Matrigel matrix. Biotechniques. May 2012;52(5):307-315. [PubMed Abstract]

Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF. Identification of a Ckit+ Colonic Crypt Base Secretory Cell that Supports Lgr5+ Stem Cells in Mice. Gastroenterology 2012. [PubMed Abstract]

Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, Sansom O, Fodde R: Paneth cells in intestinal homeostasis and tissue injury. PLoS One 2012, 7:e38965. [PubMed Abstract]

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012;337(6095):730-5. [PubMed Abstract]

Singh SR, Mishra MK, Kango-Singh M, Hou SX. Generation and staining of intestinal stem cell lineage in adult midgut. Methods Mol Biol 2012;879:47-69. [PubMed Abstract]

Smith NR, Davies PS, Silk AD, Wong MH. Epithelial and Mesenchymal Contribution to the Niche: A Safeguard to Intestinal Stem Cell Homeostasis. Gastroenterology 2012. [PubMed Abstract]

Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E 2012 Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Scientific reports 2:568 [PubMed Abstract]

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F. Cdx2 determines the fate of postnatal intestinal endoderm. Development 2012;139(3):465-74. [PubMed Abstract]

Uehara T, Ma D, Yao Y, et al. H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem Cells in the Stomach of Patients with Gastric Cancer. Dig Dis Sci. Sep 4 2012. [PubMed Abstract]

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud A, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 2012;139(3):488-97. [PubMed Abstract]

Van Landeghem L, Santoro MA, Krebs AE, Mah AT, Dehmer JJ, Gracz AD, Scull BP, McNaughton K, Magness ST, Lund PK. Activation of two distinct Sox9-EGFP expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 2012. [PubMed Abstract]

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 2012;14(4):401-8. [PubMed Abstract]

Yilmaz OH, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. Jun 28 2012;486(7404):490-495. [PubMed Abstract]

Yoon, J. K.; Lee, J. S. Cellular signaling and biological functions of R-spondins. Cell Signal 24(2):369-377; 2012. [PubMed Abstract]

Yu T, Chen X, Zhang W, et al. Kruppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PLoS One. 2012;7(2):e32492. [PubMed Abstract]

Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell. Nat Med 2012;18(4):618-23. [PubMed Abstract]

Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. FGF signaling facilitates post-injury recovery of mouse hematopoietic system. Blood 2012. [PubMed Abstract]
Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH. The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers (Basel) 2011;3(1):319-339. [PubMed Abstract]

Cao L, Gibson JD, Miyamoto S, Sail V, Verma R, Rosenberg DW, Nelson CE, Giardina C. Intestinal lineage commitment of embryonic stem cells. Differentiation 2011;81(1):1-10. [PubMed Abstract]

Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, Visser B, Hisamori S, Shimono Y, van de Wetering M, Clevers H, Clarke MF, Quake SR. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotech 2011;29(12):1120-1127. [PubMed Abstract]

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. A small molecule differentiation inducer increases insulin production by pancreatic beta cells. Proc Natl Acad Sci U S A 2011;108(51):20713-8. [PubMed Abstract]

Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER. Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology 2011;141(3):1003-1013 e1-10. [PubMed Abstract]

Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol 2011;192(5):767-80. [PubMed Abstract]

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine-Induction of Tumor Necrosis Factor Receptor 2 (TNFR2) is Mediated by STAT3 in Colon Cancer Cells. Mol Cancer Res 2011. [PubMed Abstract]

Jung P, Sato T, Merlos-Suarez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E. Isolation and in vitro expansion of human colonic stem cells. Nat Med 2011;17(10):1225-7. [PubMed Abstract]

Kunii J, Takahashi K, Kasakura K, Tsuda M, Nakano K, Hosono A, Kaminogawa S. Commensal bacteria promote migration of mast cells into the intestine. Immunobiology 2011;216(6):692-7. [PubMed Abstract]

Merlos-Suarez A, Barriga FM, Jung P, Iglesias M, Cespedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Munoz P, Clevers H, Sancho E, Mangues R, Batlle E. The Intestinal Stem Cell SignatureIdentifies Colorectal Cancer Stem Cells and Predicts Disease Relapse. Cell Stem Cell 2011. [PubMed Abstract]

Mongroo, P. S.; Noubissi, F. K.; Cuatrecasas, M.; Kalabis, J.; King, C. E.; Johnstone, C. N.; Bowser, M. J.; Castells, A.; Spiegelman, V. S.; Rustgi, A. K. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res 71(6):2172-2182; 2011 [PubMed Abstract]

Monroe, M. M.; Anderson, E. C.; Clayburgh, D. R.; Wong, M. H. Cancer stem cells in head and neck squamous cell carcinoma. J Oncol 2011:762780; 2011. [PubMed Abstract]

Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. PLoS One 2011;6(10):e26816. [PubMed Abstract]

Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev 2011;25(18):1928-42. [PubMed Abstract]

Mustata RC, Van Loy T, Lefort A, Libert F, Strollo S, Vassart G, Garcia MI. Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep 2011;12(6):558-64. [PubMed Abstract]

Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, Wong MH. Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 2011;71(4):1497-505. [PubMed Abstract]

Powell DW, Pinchuk IV, Saada JI, Chen X, Mifflin RC. Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol 2011;73:213-37. [PubMed Abstract]

Qin HH, Dunn JC. Small Intestinal Submucosa Seeded with Intestinal Smooth Muscle Cells in a Rodent Jejunal Interposition Model. J Surg Res 2011. [PubMed Abstract]

Ramalingam S, Daughtridge GW, Johnston MJ, Gracz AD, Magness ST. Distinct Levels of Sox9 Expression Mark Colon Epithelial Stem Cells that Form Colonoids in Culture. Am J Physiol Gastrointest Liver Physiol 2011. [PubMed Abstract]

Reizel Y, Chapal-Ilani N, Adar R, Itzkovitz S, Elbaz J, Maruvka YE, Segev E, Shlush LI, Dekel N, Shapiro E. Colon stem cell and crypt dynamics exposed by cell lineage reconstruction. PLoS Genet 2011;7(7):e1002192. [PubMed Abstract]

Sainathan SK, Bishnupuri KS, Aden K, Luo Q, Houchen CW, Anant S, Dieckgraefe BK. Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis. Inflamm Bowel Dis 2011. [PubMed Abstract]

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res 2011;71(10):3709-19. [PubMed Abstract]

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011;469(7330):415-8. [PubMed Abstract]

Sei Y, Lu X, Liou A, Zhao X, Wank SA. A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine. Am J Physiol Gastrointest Liver Physiol 2011;300(2):G345-56. [PubMed Abstract]

Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011;470(7332):105-9. [PubMed Abstract]

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Res 2011;168(1):62-9. [PubMed Abstract]

Stark R, Zupekan T, Bondada S, Dunn JC. Restoration of mechanically lengthened jejunum into intestinal continuity in rats. J Pediatr Surg 2011;46(12):2321-6. [PubMed Abstract]

Sureban SM, May R, Lightfoot S, Hoskins AB, Lerner MR, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res 2011. [PubMed Abstract]

Takeda N, Jain R, Leboeuf MR, Wang Q, Lu MM, Epstein JA. Interconversion Between Intestinal Stem Cell Populations in Distinct Niches. Science 2011. [PubMed Abstract]

Yeung TM, Gandhi SC, Bodmer WF. Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. Proc Natl Acad Sci U S A 2011;108(11):4382-7. [PubMed Abstract]
Chia LA, Kuo CJ. The intestinal stem cell. Prog Mol Biol Transl Sci 2010;96:157-73. [PubMed Abstract]

Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, Zhang L. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther 2010;9(11):2893-902. [PubMed Abstract]

Gracz AD, Ramalingam S, Magness ST. Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol. May 2010;298(5):G590-600. [PubMed Abstract]

Lan SY, Yu T, Xia ZS, Yuan YH, Shi L, Lin Y, Huang KH, Chen QK. Musashi 1-positive cells derived from mouse embryonic stem cells can differentiate into neural and intestinal epithelial-like cells in vivo. Cell Biol Int 2010;34(12):1171-80. [PubMed Abstract]

Leen JL, Izzo A, Upadhyay C, Rowland KJ, Dube PE, Gu S, Heximer SP, Rhodes CJ, Storm DR, Lund PK, Brubaker PL. Mechanism of Action of Glucagon-Like Peptide-2 to Increase IGF-I mRNA in Intestinal Subepithelial Fibroblasts. Endocrinology 2010. [PubMed Abstract]

Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 2010. [PubMed Abstract]

Pinchuk IV, Mifflin RC, Saada JI, Powell DW. Intestinal mesenchymal cells. Curr Gastroenterol Rep 2010;12(5):310-8. [PubMed Abstract]

Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M. The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J Cell Sci 2010;123(Pt 19):3256-65. [PubMed Abstract]

Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle 2010;9(15):3039-45. [PubMed Abstract]

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