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Articles of Interest

Articles of Interest to ISCC Investigators (248)

This is a list of publications that could be of interest to Investigators of Intestinal Stem Cell Research or related work. Authors names that are in bold represent past or present ISCC Investigators.
Bankaitis ED, Ha A, Kuo CJ, Magness ST. Reserve Stem Cells in Intestinal Homeostasis and Injury. Gastroenterology, 2018 Aug.

Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, Spence JR:  A Method for Cryogenic Preservation of Human Biopsy Specimens and Subsequent Organoid Culture. Cell Mol Gastroenterol Hepatol, Published online: May 10, 2018

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Toth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts Nature 2018 May.

Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh MK, Virshup DM: PDGFRalpha(+) pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proc Natl Acad SciU S A 2018 Apr, 115(14):E3173-E3181.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA: Identification, isolation, and characterization of human LGR5-positive colon adenoma cells. Development 2018 Feb.

Miller AJ, Hill DR, Nagy MS, Aoki Y, Dye BR, Chin AM, Huang S, Zhu F, White ES, Lama V, Spence JR: In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells. Stem Cell Reports 2018 Jan, 10(1):101-119.

Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA: Beta-catenin cleavage enhances transcriptional activation. Sci Rep 2018 Jan, 8(1):671.
Sarwer DB, Dilks RJ, Spitzer JC, Berkowitz RI, Wadden TA, Moore RH, Chittams JL, Brandt ML, Chen MK, Courcoulas AP, Harmon CM, Helmrath MA, Michalsky MP, Xanthakos SA, Zeller MH, Jenkins TM, Inge TH: Changes in Dietary Intake and Eating Behavior in Adolescents After Bariatric Surgery: an Ancillary Study to the Teen-LABS Consortium. Obes Surg 2017 Dec, 27(12):3082-3091.

Hill DR, Huang S, Tsai YH, Spence JR, Young VB: Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids. J Vis Exp 2017 Dec(130).

Smith AR, Kuo CJ. Organoids lead the cancer attack. Nat Med, 2017 Dec, 23(12): 1399-400.

Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Gyorffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM: Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A 2017 Nov, 114(45):E9608-E9617.

Chen Y, Zhou W, Roh T, Estes MK, Kaplan DL. In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses. PLoS One, 2017 Nov, 12(11): e0187880. PMCID: 5706668

Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK: Gastrointestinal microphysiological systems. Exp Biol Med (Maywood) 2017 Oct, 242(16):1633-1642.

Laucirica DR, Triantis V, Schoemaker R, Estes MK, Ramani S: Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells. J Nutr 2017 Sep, 147(9):1709-1714.

Tadesse S, Corner G, Dhima E, Houston M, Guha C, Augenlicht L, Velcich A: MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa. Oncotarget 2017 Sep, 8(42):71456-71470.

Schlieve CR, Fowler KL, Thornton M, Huang S, Hajjali I, Hou X, Grubbs B, Spence JR, Grikscheit TC: Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine. Stem Cell Reports 2017 Sep, 9(3):883-896.

Laczko D, Wang F, Johnson FB, Jhala N, Rosztoczy A, Ginsberg GG, Falk GW, Rustgi AK, Lynch JP: Modeling Esophagitis Using Human Three-Dimensional Organotypic Culture System. Am J Pathol 2017 Aug, 187(8):1787-1799.

Xu L, Cheng D, Huang Z, Ding S, Zhang W, Tan H, Shi H, Chen R, Zou Y, Wang TC, Yang X, Ge J: Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway. Atherosclerosis 2017 Aug, 263:42-52.

Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD : An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell 2017 Jul, 21(1):91-106 e106.

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF. SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of beta-catenin. Gastroenterology, 2017 Jul, 153(1): 205-18 e8.

Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC: Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut 2017 Jun, 66(6):1001-1011.

Kim GA, Spence JR, Takayama S: Bioengineering for intestinal organoid cultures. Curr Opin Biotechnol 2017 Jun, 47:51-58.

Greer SU, Nadauld LD, Lau BT, Chen J, Wood-Bouwens C, Ford JM, Kuo CJ, Ji HP: Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases. Genome Med 2017 Jun, 9(1):57.

Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD: Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res 2017 Jun:22034517717255.

Xu B, Li H, Perry JM, Singh VP, Unruh J, Yu Z, Zakari M, McDowell W, Li L, Gerton JL: Ribosomal DNA copy number loss and sequence variation in cancer. J PLoS Genet 2017 Jun, 13(6):e1006771.

Marcinkowski EF, Ottesen R, Niland J, Vito C. Acceptance of adjuvant chemotherapy recommendations in early-stage hormone-positive breast cancer. J Surg Res, 2017 Jun, 214: 79-85.

Lal DR, Gadepalli SK, Downard CD, Ostlie DJ, Minneci PC, Swedler RM, Chelius TH, Cassidy L, Rapp CT, Billmire D, Bruch S, Burns RC, Deans KJ, Fallat ME, Fraser JD, Grabowski J, Hebel F, Helmrath MA, Hirschl RB, Kabre R, Kohler J, Landman MP, Leys CM, Mak GZ, Raque J, Rymeski B, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT, Midwest Pediatric Surgery C: Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium. J Pediatr Surg 2017 Jun.

Shanker S, Hu L, Ramani S, Atmar RL, Estes MK, Venkataram Prasad BV: Structural features of glycan recognition among viral pathogens. Curr Opin Struct Biol 2017 Jun, 44:211-218.

Jin G, Sakitani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC: The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. Oncotarget 2017 Jun, 8(25):40606-40619.

Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL. A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium. Biomaterials, 2017 Jun, 128: 44-55. PMCID: 5392043.

Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I: Challenges and emerging directions in single-cell analysis. Genome Biol 2017 May, 18(1):84.

Miller AJ, Spence JR: In Vitro Models to Study Human Lung Development, Disease and Homeostasis. Physiology (Bethesda) 2017 May, 32(3):246-260.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA: (Re)Building a Kidney. J Am Soc Nephrol 2017 May, 28(5):1370-1378.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death Differ, 2017 May, 24(5): 855-65. PMCID: 5423110.

Shao Y, Taniguchi K, Gurdziel K, Townshend RF, Xue X, Yong KMA, Sang J, Spence JR, Gumucio DL, Fu J: Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater 2017 Apr, 16(4):419-425.

von Burstin J, Bachhuber F, Paul M, Schmid RM, Rustgi AK: The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells. Mol Carcinog 2017 Mar, 56(3):936-944.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Sci Rep 2017 Mar, 7:45270.

Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H: Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell Rep 2017 Mar, 18(11):2608-2621.

Arora N, Imran Alsous J, Guggenheim JW, Mak M, Munera J, Wells JM, Kamm RD, Asada HH, Shvartsman SY, Griffith LG: A process engineering approach to increase organoid yield. Development 2017 Mar, 144(6):1128-1136.

Fendler W, Malachowska B, Meghani K, Konstantinopoulos PA, Guha C, Singh VK, Chowdhury D: Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med 2017 Mar, 9(379).

Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK: Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol 2017 Mar.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes MK, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep 2017 Mar, 7:44517.

Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, Wyckoff G, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ. Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase. Cell Death Dis, 2017 Mar, 8(3): e2705. PMCID: 5386535.

Carr JS, King S, Dekaney CM. Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLoS One, 2017 Mar, 12(3): e0173429. PMCID: 5336284.

Peck BC, Mah AT, Pitman WA, Ding S, Lund PK, Sethupathy P: Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. J Biol Chem 2017 Feb, 292(7):2586-2600.

McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM: Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature 2017 Jan, 541(7636):182-187.

Brodin NP, Velcich A, Guha C, Tome WA: A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems. Dose Response 2017 Jan, 15(1):1559325816685798.

Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK: A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A 2017 Jan, 114(4):E570-E579.

Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER: BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. Elife 2017 Jan, 6.

Stzepourginski I, Nigro G, Jacob JM, Dulauroy S, Sansonetti PJ, Eberl G, Peduto L: CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury. Proc Natl Acad Sci USA 2017 Jan, 114(4):E506-E513.

Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Hohl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M. Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma. Cancer Prev Res (Phila), 2017 Jan, 10(1): 55-66. PMCID: 5219855.
Hayakawa Y, Chang W, Jin G, Wang TC: Gastrin and upper GI cancers. Curr Opin Pharmacol 2016 Dec, 31:31-37.

Meyer LA, Cronin AM, Sun CC, Bixel K, Bookman MA, Cristea MC, Griggs JJ, Levenback CF, Burger RA, Mantia-Smaldone G, Matulonis UA, Niland JC, O'Malley DM, Wright AA. Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol, 2016 Nov, 34(32): 3854-63. PMCID: 5477982.

Jadhav U, Shivdasani RA : Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol 2016 Nov, 2(6):714-715.

Kulkarni S, Koller A, Mani KM, Wen R, Alfieri A, Saha S, Wang J, Patel P, Bandeira N, Guha C, Chen EI: Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow. Int J Radiat Oncol Biol Phys 2016 Nov, 96(3):566-577.

Allen JI, Wang TC, Cohen WS, Shah VH: How to Succeed in Academic Gastroenterology. Gastroenterology 2016 Oct, 151(4):578-581 e576.

Larsen BM, Marty-Santos L, Newman M, Lukacs DT, Spence JR, Wellik DM: Hox6 genes modulate in vitro differentiation of mESCs to insulin-producing cells. In Vitro Cell Dev Biol Anim 2016 Oct, 52(9):974-982.

Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P: SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A 2016 Sep, 113(39):E5731-5740.

Sharir A, Klein OD : Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol 2016 Sep, 214(6):645-647.

Dye BR, Dedhia PH, Miller AJ, Nagy MS, White ES, Shea LD, Spence JR: A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. Elife 2016 Sep, 5.

Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science, 2016 Sep, 353(6306): 1387-93. PMCID: 5305121.

Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM. Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes, 2016 Sep, 7(5): 414-23. PMCID: 5046166.

Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinje J, Atmar RL, Estes MK. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol, 2016 Sep, 97(9): 2291-300. PMCID: 5756488.

Qian P, Li L. Single-cell RNA-seq technology lends a hand into HSC ontogeny. Sci China Life Sci, 2016 Sep, 59(9): 977-8.

Lloyd RE, Estes MK : Editorial overview: Viruses and cell metabolism. Curr Opin Virol 2016 Aug, 19: vii-viii.

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K: Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep 2016 Aug, 16(7):1929-1941.

Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C. PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol, 2016 Aug, 311(2): G221-36. PMCID: 5007290.

Dye BR, Miller AJ, Spence JR. How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells. Curr Pathobiol Rep, 2016 Jun, 4: 47-57. PMCID: 4882378.

Rankin SA, Han L, McCracken KW, Kenny AP, Anglin CT, Grigg EA, Crawford CM, Wells JM, Shannon JM, Zorn AM. A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification. Cell Rep, 2016 Jun, 16(1): 66-78. PMCID: 5314425.

Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW. Kruppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following gamma-Radiation-Induced Gut Injury in Mice. Stem Cell Reports, 2016 Jun, 6(6): 815-24. PMCID: 4911500.

Attayek PJ, Ahmad AA, Wang Y, Williamson I, Sims CE, Magness ST, Allbritton NL. In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment. PLoS One, 2016 Apr, 11(4): e0153795. PMCID: 4839657.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M: Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology 2016 Mar, 150(3):638-649 e638.

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q: Reprogrammed Stomach Tissue as a Renewable Source of Functional beta Cells for Blood Glucose Regulation. Cell Stem Cell 2016 Mar, 18(3):410-421.

Kim TH, Shivdasani RA: Stomach development, stem cells and disease. Development 2016 Feb, 143(4):554-565.

Dubeykovskaya Z, Si Y, Chen X, Worthley DL, Renz BW, Urbanska AM, Hayakawa Y, Xu T, Westphalen CB, Dubeykovskiy A, Chen D, Friedman RA, Asfaha S, Nagar K, Tailor Y, Muthupalani S, Fox JG, Kitajewski J, Wang TC: Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nat Commun 2016 Feb, 7:10517.

Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH: Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell Mol Gastroenterol Hepatol 2016 Feb, 2(2):175-188.

Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell, 2016 Feb, 18(2): 214-28. PMCID: 5545934.

Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA. A Cytosolic Multiprotein Complex Containing p85alpha Is Required for beta-Catenin Activation in Colitis and Colitis-associated Cancer. J Biol Chem, 2016 Feb, 291(8): 4166-77. PMCID: 4759191.

Rabben HL, Zhao CM, Hayakawa Y, Wang TC, Chen D: Vagotomy and Gastric Tumorigenesis. Curr Neuropharmacol 2016 Jan, 14(8):967-972.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR, Teen LC. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med, 2016 Jan, 374(2): 113-23. PMCID: 4810437.
Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM: Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 2015 Dec, 528(7583):560-564.

Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L: Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol 2015 Dec, 309(12):G975-987.

Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC: Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 2015 Dec, 28(6):800-814.

Taniguchi K, Shao Y, Townshend RF, Tsai YH, DeLong CJ, Lopez SA, Gayen S, Freddo AM, Chue DJ, Thomas DJ, Spence JR, Margolis B, Kalantry S, Fu J, O'Shea KS, Gumucio DL. Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells. Stem Cell Reports, 2015 Dec, 5(6): 954-62. PMCID: 4682207.

Zhao M, Li L. Regulation of hematopoietic stem cells in the niche. Sci China Life Sci, 2015 Dec, 58(12): 1209-15.

San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA: Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports 2015 Nov, 5(5):673-681.

Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA: SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol 2015 Nov, 1(6):598-609 e596.

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST. SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. Gastroenterology, 2015 Nov, 149(6): 1553-63 e10. PMCID: 4709179.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK: Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol 2015 Oct, 90(1):43-56.

Santoro MA, Blue RE, Andres SF, Mah AT, Van Landeghem L, Lund PK. Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. Am J Physiol Gastrointest Liver Physiol, 2015 Oct, 309(7): G578-89. PMCID: 4593818.

Jayewickreme CD, Shivdasani RA : Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol 2015 Sep, 405(1):21-32.

Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS: Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. J Clin Invest 2015 Sep, 125(9):3606-3618.

Davies JM, Santaolalla R, von Furstenberg RJ, Henning SJ, Abreu MT. The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures. PLoS One, 2015 Sep, 10(9): e0138531. PMCID: 4587363.

Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinje J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM: Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol 2015 Aug, 22(8):923-929.

Sureban SM, Qu D, Houchen CW : Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. Curr Pharmacol Rep 2015 Aug, 1(4):217-222.

Hrycaj SM, Dye BR, Baker NC, Larsen BM, Burke AC, Spence JR, Wellik DM. Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development. Cell Rep, 2015 Aug, 12(6): 903-12. PMCID: 4536095.

Shi Z, Chiang CI, Labhart P, Zhao Y, Yang J, Mistretta TA, Henning SJ, Maity SN, Mori-Akiyama Y: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. Nucleic Acids Res 2015 Jul, 43(13):6257-6269.

Yusung SA, Martin MG : A Breath of Fresh AIRE Surrounds Paneth Cells and Defensins. Gastroenterology2015 Jul, 149(1):22-25.

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