Articles of Interest

Solorzano-Vargas RS, Bjerknes M, Wang J, Wu SV, Garcia-Careaga MG, Pisit D, Cheng H, German MS, Georgia S, Martin MG. Null mutations of NEUROG3 are associated with delayed onset diabetes mellitus. JCI Insight, 2019 Dec.

Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, Chandra D, O'Connor MH, Mertelsmann AM, Vinci P, Kuttiyara J, Devlin SM, Middendorp S, Calafiore M, Egorova A, Kleppe M, Lo Y, Shroyer NF, Cheng EH, Levine RL, Liu C, Kolesnick R, Lindemans CA, Hanash AM. T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage. Sci Immunol, 2019 Dec, 4(42). PMCID: PMC7239329.

Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM. a href="http://www.ncbi.nlm.nih.gov/pubmed/31178402" target=”_blank”>A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Dev Cell, 2019 Aug, 50(3): 367-80 e7. PMCID: 7082840.

Estes MK, Ettayebi K, Tenge VR, Murakami K, Karandikar U, Lin SC, Ayyar BV, Cortes-Penfield NW, Haga K, Neill FH, Opekun AR, Broughman JR, Zeng XL, Blutt SE, Crawford SE, Ramani S, Graham DY, Atmar RL: Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges. Viruses, 2019 Jul 11, 11(7).

Dekaney CM, King S, Sheahan B, Cortes JE. Mist1 Expression Is Required for Paneth Cell Maturation. Cell Mol Gastroenterol Hepatol, 2019 Jul Epub, 8(4): 549-60. PMCID: 6889789.

Fasciano AC, Blutt SE, Estes MK, Mecsas J. Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. J Vis Exp, 2019 Jul, (149). PMCID: PMC6755909.

Li Z, He XC, Li L: Hematopoietic stem cells: self-renewal and expansion. Curr Opin Hematol, 2019 Jul, 26(4):258-265.

Zwarycz B, Gracz AD, Rivera KR, Williamson IA, Samsa LA, Starmer J, Daniele MA, Salter-Cid L, Zhao Q, Magness ST. IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model. Cell Mol Gastroenterol Hepatol, 2019 Jul, 7(1): 1-17. PMCID: 6199238.

Marchelletta R, Yu J, Moon C, Kim MM. Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology. Curr Protoc Pharmacol, 2019 Jun, 85(1): e54.

Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, Fink M, Barutcu S, Trcka D, Shen J, Chan K, Wrana JL, Gregorieff A. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature, 2019 May, 569(7754): 121-5.

Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol, 2019 Apr, 8(2): 209-29. PMCID: PMC6664234.

Gonzalez LM, Stewart AS, Freund J, Kucera CR, Dekaney CM, Magness ST, Blikslager AT. Preservation of reserve intestinal epithelial stem cells following severe ischemic injury. Am J Physiol Gastrointest Liver Physiol, 2019 Apr, 316(4): G482-G94. PMCID: 6483022.

Jones JC, Brindley CD, Elder NH, Myers MG, Jr., Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ. Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cell Mol Gastroenterol Hepatol, 2019 Apr, 7(3): 533-54. PMCID: 6402430.

Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK. Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol, 2019 Apr, 1576: 229-47. PMCID: PMC5752619.

Co JY, Margalef-Catala M, Li X, Mah AT, Kuo CJ, Monack DM, Amieva MR. Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions. Cell Rep, 2019 Feb, 26(9): 2509-20 e4. PMCID: 6391775.

Dubrovsky G, Huynh N, Thomas AL, Shekherdimian S, Dunn JC. Double plication for spring-mediated in-continuity intestinal lengthening in a porcine model. Surgery, 2019 Feb, 165(2): 389-92.

Jadhav U, Shivdasani RA. Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell, 2019 Feb, 176(5): 949-51.

Miller AJ, Dye BR, Ferrer-Torres D, Hill DR, Overeem AW, Shea LD, Spence JR. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc, 2019 Feb, 14(2): 518-40.

Dubrovsky G, Huynh N, Thomas AL, Shekherdimian S, Dunn JC. Intestinal lengthening via multiple in-continuity springs. J Pediatr Surg, 2019 Jan, 54(1): 39-43.

Gehart H, Clevers H. Tales from the crypt: new insights into intestinal stem cells. Nat Rev Gastroenterol Hepatol, 2019 Jan, 16(1): 19-34.

Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells. Cell Rep, 2019 Jan Epub, 26(3): 652-69 e6.

Hill DR, Huang S, Tsai YH, Spence JR, Young VB: Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids. J Vis Exp 2017 Dec(130).

Sarwer DB, Dilks RJ, Spitzer JC, Berkowitz RI, Wadden TA, Moore RH, Chittams JL, Brandt ML, Chen MK, Courcoulas AP, Harmon CM, Helmrath MA, Michalsky MP, Xanthakos SA, Zeller MH, Jenkins TM, Inge TH: Changes in Dietary Intake and Eating Behavior in Adolescents After Bariatric Surgery: an Ancillary Study to the Teen-LABS Consortium. Obes Surg 2017 Dec, 27(12):3082-3091.

Smith AR, Kuo CJ. Organoids lead the cancer attack. Nat Med, 2017 Dec, 23(12): 1399-400.

Chen Y, Zhou W, Roh T, Estes MK, Kaplan DL. In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses. PLoS One, 2017 Nov, 12(11): e0187880. PMCID: 5706668

Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Gyorffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM: Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A 2017 Nov, 114(45):E9608-E9617.

Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. Gastroenterology, 2017 Oct, 153(4): 1040-53 e4.

Laucirica DR, Triantis V, Schoemaker R, Estes MK, Ramani S: Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells. J Nutr 2017 Sep, 147(9):1709-1714.

Schlieve CR, Fowler KL, Thornton M, Huang S, Hajjali I, Hou X, Grubbs B, Spence JR, Grikscheit TC: Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine. Stem Cell Reports 2017 Sep, 9(3):883-896.

Tadesse S, Corner G, Dhima E, Houston M, Guha C, Augenlicht L, Velcich A: MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa. Oncotarget 2017 Sep, 8(42):71456-71470.

Laczko D, Wang F, Johnson FB, Jhala N, Rosztoczy A, Ginsberg GG, Falk GW, Rustgi AK, Lynch JP: Modeling Esophagitis Using Human Three-Dimensional Organotypic Culture System. Am J Pathol 2017 Aug, 187(8):1787-1799.

Xu L, Cheng D, Huang Z, Ding S, Zhang W, Tan H, Shi H, Chen R, Zou Y, Wang TC, Yang X, Ge J: Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway. Atherosclerosis 2017 Aug, 263:42-52.

Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD : An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell 2017 Jul, 21(1):91-106 e106.

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF. SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of beta-catenin. Gastroenterology, 2017 Jul, 153(1): 205-18 e8.

Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC: Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut 2017 Jun, 66(6):1001-1011.

Greer SU, Nadauld LD, Lau BT, Chen J, Wood-Bouwens C, Ford JM, Kuo CJ, Ji HP: Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases. Genome Med 2017 Jun, 9(1):57.

Jin G, Sakitani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC: The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. Oncotarget 2017 Jun, 8(25):40606-40619.

Lal DR, Gadepalli SK, Downard CD, Ostlie DJ, Minneci PC, Swedler RM, Chelius TH, Cassidy L, Rapp CT, Billmire D, Bruch S, Burns RC, Deans KJ, Fallat ME, Fraser JD, Grabowski J, Hebel F, Helmrath MA, Hirschl RB, Kabre R, Kohler J, Landman MP, Leys CM, Mak GZ, Raque J, Rymeski B, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT, Midwest Pediatric Surgery C: Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium. J Pediatr Surg 2017 Jun.

Marcinkowski EF, Ottesen R, Niland J, Vito C. Acceptance of adjuvant chemotherapy recommendations in early-stage hormone-positive breast cancer. J Surg Res, 2017 Jun, 214: 79-85.

Prochazkova M, Hakkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development, 2017 Jun, 144(12): 2212-21. PMCID: 5482992.

Shanker S, Hu L, Ramani S, Atmar RL, Estes MK, Venkataram Prasad BV: Structural features of glycan recognition among viral pathogens. Curr Opin Struct Biol 2017 Jun, 44:211-218.

Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL. A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium. Biomaterials, 2017 Jun, 128: 44-55. PMCID: 5392043.
Xu B, Li H, Perry JM, Singh VP, Unruh J, Yu Z, Zakari M, McDowell W, Li L, Gerton JL: Ribosomal DNA copy number loss and sequence variation in cancer. J PLoS Genet 2017 Jun, 13(6):e1006771.

Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD: Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res 2017 Jun:22034517717255.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death Differ, 2017 May, 24(5): 855-65. PMCID: 5423110.

Miller AJ, Spence JR: In Vitro Models to Study Human Lung Development, Disease and Homeostasis. Physiology (Bethesda) 2017 May, 32(3):246-260.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA: (Re)Building a Kidney. J Am Soc Nephrol 2017 May, 28(5):1370-1378.

Seidel K, Marangoni P, Tang C, Houshmand B, Du W, Maas RL, Murray S, Oldham MC, Klein OD. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. Elife, 2017 May Epub, 6. PMCID: 5419740.

Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I: Challenges and emerging directions in single-cell analysis. Genome Biol 2017 May, 18(1):84.

Shao Y, Taniguchi K, Gurdziel K, Townshend RF, Xue X, Yong KMA, Sang J, Spence JR, Gumucio DL, Fu J: Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater 2017 Apr, 16(4):419-425.

Arora N, Imran Alsous J, Guggenheim JW, Mak M, Munera J, Wells JM, Kamm RD, Asada HH, Shvartsman SY, Griffith LG: A process engineering approach to increase organoid yield. Development 2017 Mar, 144(6):1128-1136.

Carr JS, King S, Dekaney CM. Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLoS One, 2017 Mar, 12(3): e0173429. PMCID: 5336284.

Fendler W, Malachowska B, Meghani K, Konstantinopoulos PA, Guha C, Singh VK, Chowdhury D: Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med 2017 Mar, 9(379).

Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H: Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell Rep 2017 Mar, 18(11):2608-2621.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Sci Rep 2017 Mar, 7:45270.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes MK, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep 2017 Mar, 7:44517.

von Burstin J, Bachhuber F, Paul M, Schmid RM, Rustgi AK: The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells. Mol Carcinog 2017 Mar, 56(3):936-944.

Yang TB, Chen Q, Deng JT, Jagannathan G, Tobias JW, Schultz DC, Wang S, Lengner CJ, Rustgi AK, Lynch JP, Johnson FB. Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche. Nat Commun, 2017 Mar Epub, 8: 14766. PMCID: 5357864.

Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, Wyckoff G, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ. Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase. Cell Death Dis, 2017 Mar, 8(3): e2705. PMCID: 5386535.

Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK: Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol 2017 Mar.

Peck BC, Mah AT, Pitman WA, Ding S, Lund PK, Sethupathy P: Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. J Biol Chem 2017 Feb, 292(7):2586-2600.

Brodin NP, Velcich A, Guha C, Tome WA: A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems. Dose Response 2017 Jan, 15(1):1559325816685798.

McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM: Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature 2017 Jan, 541(7636):182-187.

Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER: BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. Elife 2017 Jan, 6.

Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK: A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A 2017 Jan, 114(4):E570-E579.

Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Hohl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M. Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma. Cancer Prev Res (Phila), 2017 Jan, 10(1): 55-66. PMCID: 5219855.

Stzepourginski I, Nigro G, Jacob JM, Dulauroy S, Sansonetti PJ, Eberl G, Peduto L: CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury. Proc Natl Acad Sci USA 2017 Jan, 114(4):E506-E513.

Saxena M, Roman AKS, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA. Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev, 2017 Dec 1, 31(23-24): 2391-404. PMCID: 5795785.

Hayakawa Y, Chang W, Jin G, Wang TC: Gastrin and upper GI cancers. Curr Opin Pharmacol 2016 Dec, 31:31-37.

Jadhav U, Shivdasani RA : Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol 2016 Nov, 2(6):714-715.

Kulkarni S, Koller A, Mani KM, Wen R, Alfieri A, Saha S, Wang J, Patel P, Bandeira N, Guha C, Chen EI: Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow. Int J Radiat Oncol Biol Phys 2016 Nov, 96(3):566-577.

Meyer LA, Cronin AM, Sun CC, Bixel K, Bookman MA, Cristea MC, Griggs JJ, Levenback CF, Burger RA, Mantia-Smaldone G, Matulonis UA, Niland JC, O'Malley DM, Wright AA. Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol, 2016 Nov, 34(32): 3854-63. PMCID: 5477982.

Allen JI, Wang TC, Cohen WS, Shah VH: How to Succeed in Academic Gastroenterology. Gastroenterology 2016 Oct, 151(4):578-581 e576.

Larsen BM, Marty-Santos L, Newman M, Lukacs DT, Spence JR, Wellik DM: Hox6 genes modulate in vitro differentiation of mESCs to insulin-producing cells. In Vitro Cell Dev Biol Anim 2016 Oct, 52(9):974-982.

Dye BR, Dedhia PH, Miller AJ, Nagy MS, White ES, Shea LD, Spence JR: A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. Elife 2016 Sep, 5.

Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science, 2016 Sep, 353(6306): 1387-93. PMCID: 5305121.

Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinje J, Atmar RL, Estes MK. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol, 2016 Sep, 97(9): 2291-300. PMCID: 5756488.

Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P: SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A 2016 Sep, 113(39):E5731-5740.

Qian P, Li L. Single-cell RNA-seq technology lends a hand into HSC ontogeny. Sci China Life Sci, 2016 Sep, 59(9): 977-8.

Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM. Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes, 2016 Sep, 7(5): 414-23. PMCID: 5046166.

Sharir A, Klein OD : Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol 2016 Sep, 214(6):645-647.

Lloyd RE, Estes MK : Editorial overview: Viruses and cell metabolism. Curr Opin Virol 2016 Aug, 19: vii-viii.

Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C. PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol, 2016 Aug, 311(2): G221-36. PMCID: 5007290.

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K: Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep 2016 Aug, 16(7):1929-1941.

Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y. Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol, 2016 Jun Epub, 1422: 23-31.

Dye BR, Miller AJ, Spence JR. How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells. Curr Pathobiol Rep, 2016 Jun, 4: 47-57. PMCID: 4882378.

Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW. Kruppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following gamma-Radiation-Induced Gut Injury in Mice. Stem Cell Reports, 2016 Jun, 6(6): 815-24. PMCID: 4911500.

Rankin SA, Han L, McCracken KW, Kenny AP, Anglin CT, Grigg EA, Crawford CM, Wells JM, Shannon JM, Zorn AM. A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification. Cell Rep, 2016 Jun, 16(1): 66-78. PMCID: 5314425.

Scott A, Rouch JD, Huynh N, Chiang E, Shekherdimian S, Lee SL, Wu BM, Dunn JC. Mechanical lengthening in multiple intestinal segments in-series. J Pediatr Surg, 2016 Jun, 51(6): 957-9.

Attayek PJ, Ahmad AA, Wang Y, Williamson I, Sims CE, Magness ST, Allbritton NL. In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment. PLoS One, 2016 Apr, 11(4): e0153795. PMCID: 4839657.

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q: Reprogrammed Stomach Tissue as a Renewable Source of Functional beta Cells for Blood Glucose Regulation. Cell Stem Cell 2016 Mar, 18(3):410-421.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M: Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology 2016 Mar, 150(3):638-649 e638.

Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH: Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell Mol Gastroenterol Hepatol 2016 Feb, 2(2):175-188.

Dubeykovskaya Z, Si Y, Chen X, Worthley DL, Renz BW, Urbanska AM, Hayakawa Y, Xu T, Westphalen CB, Dubeykovskiy A, Chen D, Friedman RA, Asfaha S, Nagar K, Tailor Y, Muthupalani S, Fox JG, Kitajewski J, Wang TC: Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nat Commun 2016 Feb, 7:10517.

Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA. A Cytosolic Multiprotein Complex Containing p85alpha Is Required for beta-Catenin Activation in Colitis and Colitis-associated Cancer. J Biol Chem, 2016 Feb, 291(8): 4166-77. PMCID: 4759191.

Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell, 2016 Feb, 18(2): 214-28. PMCID: 5545934.

In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O. Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol, 2016 Jan, 2(1): 48-62 e3. PMCID: 4740923.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR, Teen LC. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med, 2016 Jan, 374(2): 113-23. PMCID: 4810437.

Rabben HL, Zhao CM, Hayakawa Y, Wang TC, Chen D: Vagotomy and Gastric Tumorigenesis. Curr Neuropharmacol 2016 Jan, 14(8):967-972.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol, 2016 Jan, 90(1): 43-56. PMCID: 4702582.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol, 2016 Jan, 90(1): 43-56. PMCID: 4702582.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM: Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 2015 Dec, 528(7583):560-564.

Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L: Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol 2015 Dec, 309(12):G975-987.

Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC: Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 2015 Dec, 28(6):800-814.

Taniguchi K, Shao Y, Townshend RF, Tsai YH, DeLong CJ, Lopez SA, Gayen S, Freddo AM, Chue DJ, Thomas DJ, Spence JR, Margolis B, Kalantry S, Fu J, O'Shea KS, Gumucio DL. Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells. Stem Cell Reports, 2015 Dec, 5(6): 954-62. PMCID: 4682207.

San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA: Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports 2015 Nov, 5(5):673-681.

Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA: SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol 2015 Nov, 1(6):598-609 e596.

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST. SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. Gastroenterology, 2015 Nov, 149(6): 1553-63 e10. PMCID: 4709179.

Santoro MA, Blue RE, Andres SF, Mah AT, Van Landeghem L, Lund PK. Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. Am J Physiol Gastrointest Liver Physiol, 2015 Oct, 309(7): G578-89. PMCID: 4593818.

Jayewickreme CD, Shivdasani RA : Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol 2015 Sep, 405(1):21-32.

Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS: Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. J Clin Invest 2015 Sep, 125(9):3606-3618.

Davies JM, Santaolalla R, von Furstenberg RJ, Henning SJ, Abreu MT. The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures. PLoS One, 2015 Sep, 10(9): e0138531. PMCID: 4587363.

Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinje J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM: Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol 2015 Aug, 22(8):923-929.

Sureban SM, Qu D, Houchen CW : Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. Curr Pharmacol Rep 2015 Aug, 1(4):217-222.

Hrycaj SM, Dye BR, Baker NC, Larsen BM, Burke AC, Spence JR, Wellik DM. Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development. Cell Rep, 2015 Aug, 12(6): 903-12. PMCID: 4536095.

Shi Z, Chiang CI, Labhart P, Zhao Y, Yang J, Mistretta TA, Henning SJ, Maity SN, Mori-Akiyama Y: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. Nucleic Acids Res 2015 Jul, 43(13):6257-6269.

Yusung SA, Martin MG : A Breath of Fresh AIRE Surrounds Paneth Cells and Defensins. Gastroenterology2015 Jul, 149(1):22-25.

Van Landeghem L, Santoro MA, Mah AT, Krebs AE, Dehmer JJ, McNaughton KK, Helmrath MA, Magness ST, Lund PK: IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J 2015 Jul, 29(7):2828-2842.

Henning SJ, Estes MK. Women in Science: Hints for Success. Gastroenterology, 2015 Jul, 149(1): 10-3. PMCID: 4949163.

Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L: Fibulin-5 inhibits Wnt/beta-catenin signaling in lung cancer. Oncotarget 2015 Jun, 6(17):15022-15034.

Rodansky ES, Johnson LA, Huang S, Spence JR, Higgins PD. Intestinal organoids: a model of intestinal fibrosis for evaluating anti-fibrotic drugs. Exp Mol Pathol, 2015 Jun, 98(3): 346-51.

Sato T, Clevers H: SnapShot: Growing Organoids from Stem Cells. Cell 2015 Jun 18, 161(7):1700-1700 e1701.

Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development, 2015 Jun, 142(12): 2147-62. PMCID: 4483769.

Acharya SS, Fendler W, Watson J, Hamilton A, Pan Y, Gaudiano E, Moskwa P, Bhanja P, Saha S, Guha C, Parmar K, Chowdhury D: Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury. Sci Transl Med 2015 May, 7(287):287ra269.

Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y: The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol 2015 Apr, 593(8):1809-1827.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS: Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am J Physiol Gastrointest Liver Physiol 2015 Mar, 308(6):G562-571.

Goldman DC, Alexeev V, Lash E, Guha C, Rodeck U, Fleming WH: The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Radiat Res 2015 Mar, 183(3):338-344.

Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife, 2015 Mar, 4. PMCID: 4370217.

Kishimoto M, Fukui T, Suzuki R, Takahashi Y, Sumimoto K, Okazaki T, Sakao M, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K: Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle. Dig Dis Sci 2015 Feb, 60(2):362-374.

P OB, Vaitheesvaran B, Saha S, Hartil K, Chen EI, Goldman D, Fleming WH, Kurland IJ, Guha C, Golden A: Intestinal microbiota-derived metabolomic blood plasma markers for prior radiation injury. Int J Radiat Oncol Biol Phys 2015 Feb, 91(2):360-367.

Andres SF, Santoro MA, Mah AT, Keku JA, Bortvedt AE, Blue RE, Lund PK: Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs. Am J Physiol Gastrointest Liver Physiol 2015 Jan, 308(2):G100-111.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC: Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 2015 Jan, 160(1-2):269-284.

Leslie JL, Huang S, Opp JS, Nagy MS, Kobayashi M, Young VB, Spence JR. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect Immun, 2015 Jan, 83(1): 138-45. PMCID: 4288864.

Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA: An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene 2014 Dec, 33(49):5637-5648.

Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med, 2014 Nov, 20(11): 1321-6.

Basak O, van de Born M, Korving J, Beumer J, van der Elst S, van Es JH, Clevers H: Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. EMBO J 2014 Sep, 33(18):2057-2068.

Mah AT, Van Landeghem L, Gavin HE, Magness ST, Lund PK : Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1. Endocrinology 2014 Sep, 155(9):3302-3314.

Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development, 2014 Aug, 141(15): 2993-3002. PMCID: 4197660.

Koo BK, Clevers H: Stem cells marked by the R-spondin receptor LGR5. 2014 Aug, 147(2):289-302.

Liu D, He XC, Qian P, Barker N, Trainor PA, Clevers H, Liu H, Li L: Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. J Biol Chem 2014 Aug, 289(34):23809-23816.

Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, Flatberg A, Johannessen H, Friedman RA, Renz BW, Sandvik AK, Beisvag V, Tomita H, Hara A, Quante M, Li Z, Gershon MD, Kaneko K, Fox JG, Wang TC, Chen D: Denervation suppresses gastric tumorigenesis. Sci Transl Med 2014 Aug, 6(250):250ra115.

Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF: TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol 2014 Jul, 15(7):676-686.

He XC, Li Z, Sugimura R, Ross J, Zhao M, Li L. Homing and migration assays of hematopoietic stem/progenitor cells. Methods Mol Biol, 2014 Jul, 1185: 279-84.

Kinzel B, Pikiolek M, Orsini V, Sprunger J, Isken A, Zietzling S, Desplanches M, Dubost V, Breustedt D, Valdez R, Liu D, Theil D, Muller M, Dietrich B, Bouwmeester T, Ruffner H, Tchorz JS: Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol 2014 Jun, 390(2):181-190.

Lu R, Wu S, Zhang YG, Xia Y, Liu X, Zheng Y, Chen H, Schaefer KL, Zhou Z, Bissonnette M, Li L, Sun J. Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis, 2014 Jun, 3: e105. PMCID: 4150214.

Wang Y, Ahmad AA, Sims CE, Magness ST, Allbritton NL. In vitro generation of colonic epithelium from primary cells guided by microstructures. Lab Chip, 2014 May, 14(9): 1622-31. PMCID: 4037563.

Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW: Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer 2014 May, 13:103.

Ahmad AA, Wang Y, Gracz AD, Sims CE, Magness ST, Allbritton NL. Optimization of 3-D organotypic primary colonic cultures for organ-on-chip applications. J Biol Eng, 2014 Apr, 8: 9. PMCID: 4022271.

Carulli AJ, Samuelson LC, Schnell S: Unraveling intestinal stem cell behavior with models of crypt dynamics. Integr Biol (Camb) 2014 Mar, 6(3):243-257.

Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ. De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep, 2014 Mar, 6(6): 1046-58. PMCID: 4245054.

Ritsma L, Ellenbroek SIJ, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J: Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 2014 Mar, 507(7492):362-365.

Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC: Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest 2014 Mar, 124(3):1283-1295.

Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature, 2014 Feb, 506(7489): 511-5. PMCID: 4151315.

Ong BA, Vega KJ, Houchen CW : Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol 2014 Feb, 20(8):1898-1909.

San Roman AK, Jayewickreme CD, Murtaugh LC, Shivdasani RA. Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports, 2014 Feb, 2(2): 127-34. PMCID: 3923227.

Barker N: Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol 2014 Jan, 15(1):19-33.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology, 2014 Jan, 146(1): 233-44 e5. PMCID: 3870045.

Li CM, Yan HC, Fu HL, Xu GF, Wang XQ: Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells. J Anim Sci 2014 Jan, 92(1):85-94.

Tan DW, Barker N: Intestinal stem cells and their defining niche. Curr Top Dev Biol 2014 Jan, 107:77-107.

Khalil, H., Nie, W., Edwards, R.A., & Yoo, J. (2013). Isolation of primary myofibroblasts from mouse and human colon tissue. J Vis Exp, (80). PMCID: PMC3940239. [PubMed Abstract]

Akcora D, Huynh D, Lightowler S, Germann M, Robine S, de May JR, Pollard JW, Stanley ER, Malaterre J, Ramsay RG 2013 The CSF-1 receptor fashions the intestinal stem cell niche. Stem cell research 10:203-212 [PubMed Abstract]

Aust G, Kerner C, Gonsior S, Sittig D, Schneider H, Buske P, Scholz M, Dietrich N, Oldenburg S, Karpus ON, Galle J, Amasheh S, Hamann J 2013 Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Molecular biology of the cell 24:2256-2268 [PubMed Abstract]

Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ 2013 Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495:65-69 [PubMed Abstract]

Castellanos-Gonzalez A, Cabada MM, Nichols J, Gomez G, White AC, Jr. Human primary intestinal epithelial cells as an improved in vitro model for Cryptosporidium parvum infection. Infection and immunity. Jun 2013;81(6):1996-2001. [PubMed Abstract]

Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V 2013 Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. 144:381-391 [PubMed Abstract]

Folgueras AR, Guo X, Pasolli HA, Stokes N, Polak L, Zheng D, Fuchs E 2013 Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function. Cell Stem Cell 13:314-327 [PubMed Abstract]

Gemei M, Mirabelli P, Di Noto R, et al. CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo. Cancer. Feb 15 2013;119(4):729-738. [PubMed Abstract]

King SL, Dekaney CM 2013 Small intestinal stem cells. Current opinion in gastroenterology 29:140-145. [PubMed Abstract]

*King SL, Mohiuddin JJ, Dekaney CM. Paneth Cells Expand from Newly Created and Pre-existing Cells During Repair After Doxorubicin-Induced Damage. Am J Physiol Gastrointest Liver Physiol. May 9 2013. [PubMed Abstract]

Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP 2013 A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut 62:83-93. [PubMed Abstract]

Parry L, Young M, El Marjou F, Clarke AR: Evidence for A Crucial Role of Paneth Cells in Mediating the Intestinal Response to Injury. Stem Cells 2013. [PubMed Abstract]

Silk AD, Gast CE, Davies PS, Fakhari FD, Vanderbeek GE, Mori M, Wong MH 2013 Fusion between hematopoietic and epithelial cells in adult human intestine. PLoS One 8:e55572. [PubMed Abstract]

Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG, Houchen CW 2013 DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer. PLoS One 8:e73940 [PubMed Abstract]

Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem cells. 2013;31(5):992-1000. [PubMed Abstract]

Boni L, Chalajour F, Sasaki T, Snyder RL, Boyd WD, Riemer RK, Reddy VM: Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential. J Thorac Cardiovasc Surg 2012, 144:963-969 e961; discussion 969. [PubMed Abstract]

Chen, C. L.; Yu, X.; James, I. O.; Zhang, H. Y.; Yang, J.; Radulescu, A.; Zhou, Y.; Besner, G. E. Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis. Lab Invest 92(3):331-344; 2012. [PubMed Abstract]

Cordero, J. B.; Sansom, O. J. Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiol (Oxf) 204(1):137-143; 2012. [PubMed Abstract]

Davidson LA, Goldsby JS, Callaway ES, Shah MS, Barker N, Chapkin RS: Alteration of colonic stem cell gene signatures during the regenerative response to injury. Biochim Biophys Acta 2012, 1822:1600-1607. [PubMed Abstract]

de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, et al: Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol 2012, 32:3639-3647. [PubMed Abstract]

Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M: Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer 2012, 131:2242-2252. [PubMed Abstract]

Fatima, S.; Zhou, S.; Sorrentino, B. P. Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model. Stem Cells 30(2):210-221; 2012. [PubMed Abstract]

Fox RG, Magness ST, Kujoth GC, Prolla TA, Maeda N. MITOCHONDRIAL DNA POLYMERASE EDITING MUTATION, POLGD257A, DISTURBS STEM-PROGENITOR CELL CYCLING IN THE SMALL INTESTINE AND RESTRICTS EXCESS FAT ABSORPTION. Am J Physiol Gastrointest Liver Physiol 2012. [PubMed Abstract]

Fujii Y, Yoshihashi K, Suzuki H, Tsutsumi S, Mutoh H, Maeda S, Yamagata Y, Seto Y, Aburatani H, Hatakeyama M 2012 CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci U S A 109:20584-20589. [PubMed Abstract]

Gracz, A. D.; Puthoff, B. J.; Magness, S. T. Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine. Methods Mol Biol 879:89-107; 2012. [PubMed Abstract]

Hessman CJ, Bubbers EJ, Billingsley KG, Herzig DO, Wong MH. Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer. Am J Surg 2012. [PubMed Abstract]

Kalabis J, Wong GS, Vega ME, Natsuizaka M, Robertson ES, Herlyn M, Nakagawa H, Rustgi AK. Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture. Nat Protoc 2012;7(2):235-46. [PubMed Abstract]

Kim, T. H.; Escudero, S.; Shivdasani, R. A. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A 109(10):3932-3937; 2012. [PubMed Abstract]

Kushner JA. Development. Esophageal stem cells, where art thou? Science 2012;337(6098):1051-2. [PubMed Abstract]

Lund PK. Fixing the breaks in intestinal stem cells after radiation: a matter of DNA damage and death or DNA repair and regeneration. 2012;143(5):1144-7. [PubMed Abstract]

Martinez Rodriguez NR, Eloi MD, Huynh A, Dominguez T, Lam AH, Carcamo-Molina D, Naser Z, Desharnais R, Salzman NH, Porter E. Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. Infect Immun 2012;80(1):266-75. [PubMed Abstract]

Morris JF, Sul JY, Kim MS, Klein-Szanto AJ, Schochet T, Rustgi A, Eberwine JH. Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Hum Pathol 2012. [PubMed Abstract]

Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, Chiba T. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 2012. [PubMed Abstract]

Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, et al: Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem 2012, 287:37296-37308. [PubMed Abstract]

Pierzchalska M, Grabacka M, Michalik M, Zyla K, Pierzchalski P. Prostaglandin E2 supports growth of chicken embryo intestinal organoids in Matrigel matrix. Biotechniques. May 2012;52(5):307-315. [PubMed Abstract]

Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF. Identification of a Ckit+ Colonic Crypt Base Secretory Cell that Supports Lgr5+ Stem Cells in Mice. 2012. [PubMed Abstract]

Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, Sansom O, Fodde R: Paneth cells in intestinal homeostasis and tissue injury. PLoS One 2012, 7:e38965. [PubMed Abstract]

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012;337(6095):730-5. [PubMed Abstract]

Singh SR, Mishra MK, Kango-Singh M, Hou SX. Generation and staining of intestinal stem cell lineage in adult midgut. Methods Mol Biol 2012;879:47-69. [PubMed Abstract]

Smith NR, Davies PS, Silk AD, Wong MH. Epithelial and Mesenchymal Contribution to the Niche: A Safeguard to Intestinal Stem Cell Homeostasis. Gastroenterology 2012. [PubMed Abstract]

Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E 2012 Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Scientific reports 2:568 [PubMed Abstract]

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F. Cdx2 determines the fate of postnatal intestinal endoderm. Development 2012;139(3):465-74. [PubMed Abstract]

Uehara T, Ma D, Yao Y, et al. H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem Cells in the Stomach of Patients with Gastric Cancer. Dig Dis Sci. Sep 4 2012. [PubMed Abstract]

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud A, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 2012;139(3):488-97. [PubMed Abstract]

Van Landeghem L, Santoro MA, Krebs AE, Mah AT, Dehmer JJ, Gracz AD, Scull BP, McNaughton K, Magness ST, Lund PK. Activation of two distinct Sox9-EGFP expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 2012. [PubMed Abstract]

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 2012;14(4):401-8. [PubMed Abstract]

Yilmaz OH, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. Jun 28 2012;486(7404):490-495. [PubMed Abstract]

Yoon, J. K.; Lee, J. S. Cellular signaling and biological functions of R-spondins. Cell Signal 24(2):369-377; 2012. [PubMed Abstract]

Yu T, Chen X, Zhang W, et al. Kruppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PLoS One. 2012;7(2):e32492. [PubMed Abstract]

Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell. Nat Med 2012;18(4):618-23. [PubMed Abstract]

Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. FGF signaling facilitates post-injury recovery of mouse hematopoietic system. Blood 2012. [PubMed Abstract]

Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH. The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers (Basel) 2011;3(1):319-339. [PubMed Abstract]

Cao L, Gibson JD, Miyamoto S, Sail V, Verma R, Rosenberg DW, Nelson CE, Giardina C. Intestinal lineage commitment of embryonic stem cells. Differentiation 2011;81(1):1-10. [PubMed Abstract]

Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, Visser B, Hisamori S, Shimono Y, van de Wetering M, Clevers H, Clarke MF, Quake SR. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotech 2011;29(12):1120-1127. [PubMed Abstract]

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. A small molecule differentiation inducer increases insulin production by pancreatic beta cells. Proc Natl Acad Sci U S A 2011;108(51):20713-8. [PubMed Abstract]

Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER. Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology 2011;141(3):1003-1013 e1-10. [PubMed Abstract]

Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol 2011;192(5):767-80. [PubMed Abstract]

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine-Induction of Tumor Necrosis Factor Receptor 2 (TNFR2) is Mediated by STAT3 in Colon Cancer Cells. Mol Cancer Res 2011. [PubMed Abstract]

Jung P, Sato T, Merlos-Suarez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E. Isolation and in vitro expansion of human colonic stem cells. Nat Med 2011;17(10):1225-7. [PubMed Abstract]

Kunii J, Takahashi K, Kasakura K, Tsuda M, Nakano K, Hosono A, Kaminogawa S. Commensal bacteria promote migration of mast cells into the intestine. Immunobiology 2011;216(6):692-7. [PubMed Abstract]

Merlos-Suarez A, Barriga FM, Jung P, Iglesias M, Cespedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Munoz P, Clevers H, Sancho E, Mangues R, Batlle E. The Intestinal Stem Cell SignatureIdentifies Colorectal Cancer Stem Cells and Predicts Disease Relapse. Cell Stem Cell 2011. [PubMed Abstract]

Mongroo, P. S.; Noubissi, F. K.; Cuatrecasas, M.; Kalabis, J.; King, C. E.; Johnstone, C. N.; Bowser, M. J.; Castells, A.; Spiegelman, V. S.; Rustgi, A. K. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res 71(6):2172-2182; 2011 [PubMed Abstract]

Monroe, M. M.; Anderson, E. C.; Clayburgh, D. R.; Wong, M. H. Cancer stem cells in head and neck squamous cell carcinoma. J Oncol 2011:762780; 2011. [PubMed Abstract]

Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. PLoS One 2011;6(10):e26816. [PubMed Abstract]

Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev 2011;25(18):1928-42. [PubMed Abstract]

Mustata RC, Van Loy T, Lefort A, Libert F, Strollo S, Vassart G, Garcia MI. Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep 2011;12(6):558-64. [PubMed Abstract]

Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, Wong MH. Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 2011;71(4):1497-505. [PubMed Abstract]

Powell DW, Pinchuk IV, Saada JI, Chen X, Mifflin RC. Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol 2011;73:213-37. [PubMed Abstract]

Qin HH, Dunn JC. Small Intestinal Submucosa Seeded with Intestinal Smooth Muscle Cells in a Rodent Jejunal Interposition Model. J Surg Res 2011. [PubMed Abstract]

Ramalingam S, Daughtridge GW, Johnston MJ, Gracz AD, Magness ST. Distinct Levels of Sox9 Expression Mark Colon Epithelial Stem Cells that Form Colonoids in Culture. Am J Physiol Gastrointest Liver Physiol 2011. [PubMed Abstract]

Reizel Y, Chapal-Ilani N, Adar R, Itzkovitz S, Elbaz J, Maruvka YE, Segev E, Shlush LI, Dekel N, Shapiro E. Colon stem cell and crypt dynamics exposed by cell lineage reconstruction. J PLoS Genet 2011;7(7):e1002192. [PubMed Abstract]

Sainathan SK, Bishnupuri KS, Aden K, Luo Q, Houchen CW, Anant S, Dieckgraefe BK. Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis. Inflamm Bowel Dis 2011. [PubMed Abstract]

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res 2011;71(10):3709-19. [PubMed Abstract]

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011;469(7330):415-8. [PubMed Abstract]

Sei Y, Lu X, Liou A, Zhao X, Wank SA. A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine. Am J Physiol Gastrointest Liver Physiol 2011;300(2):G345-56. [PubMed Abstract]

Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011;470(7332):105-9. [PubMed Abstract]

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Res 2011;168(1):62-9. [PubMed Abstract]

Stark R, Zupekan T, Bondada S, Dunn JC. Restoration of mechanically lengthened jejunum into intestinal continuity in rats. J Pediatr Surg 2011;46(12):2321-6. [PubMed Abstract]

Sureban SM, May R, Lightfoot S, Hoskins AB, Lerner MR, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res 2011. [PubMed Abstract]

Takeda N, Jain R, Leboeuf MR, Wang Q, Lu MM, Epstein JA. Interconversion Between Intestinal Stem Cell Populations in Distinct Niches. Science 2011. [PubMed Abstract]

Yeung TM, Gandhi SC, Bodmer WF. Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. Proc Natl Acad Sci U S A 2011;108(11):4382-7. [PubMed Abstract]

Verzi, M.P.(, Shin, H., He, H.H., Sulahian, R., Meyer, C.A., Montgomery, R.K., Fleet, J.C., Brown, M., Liu, X.S., & Shivdasani, R.A.(2010). Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell, 19(5), 713-26. PMCID: PMC3001591. [PubMed Abstract]

Chia LA, Kuo CJ. The intestinal stem cell. Prog Mol Biol Transl Sci 2010;96:157-73. [PubMed Abstract]

Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, Zhang L. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther 2010;9(11):2893-902. [PubMed Abstract]

Gracz AD, Ramalingam S, Magness ST. Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol. May 2010;298(5):G590-600. [PubMed Abstract]

Lan SY, Yu T, Xia ZS, Yuan YH, Shi L, Lin Y, Huang KH, Chen QK. Musashi 1-positive cells derived from mouse embryonic stem cells can differentiate into neural and intestinal epithelial-like cells in vivo. Cell Biol Int 2010;34(12):1171-80. [PubMed Abstract]

Leen JL, Izzo A, Upadhyay C, Rowland KJ, Dube PE, Gu S, Heximer SP, Rhodes CJ, Storm DR, Lund PK, Brubaker PL. Mechanism of Action of Glucagon-Like Peptide-2 to Increase IGF-I mRNA in Intestinal Subepithelial Fibroblasts. Endocrinology 2010. [PubMed Abstract]

Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 2010. [PubMed Abstract]

Pinchuk IV, Mifflin RC, Saada JI, Powell DW. Intestinal mesenchymal cells. Curr Gastroenterol Rep 2010;12(5):310-8. [PubMed Abstract]

Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M. The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J Cell Sci 2010;123(Pt 19):3256-65. [PubMed Abstract]

Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle 2010;9(15):3039-45. [PubMed Abstract]

Schrader S, Notara M, Tuft SJ, Beaconsfield M, Geerling G, Daniels JT. Simulation of an in vitro niche environment that preserves conjunctival progenitor cells. Regen Med 2010;5(6):877-89. [PubMed Abstract]

Stairs DB, Kong J, Lynch JP. Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia. Prog Mol Biol Transl Sci 2010;96:231-70. [PubMed Abstract]

Sugimura R, Li L. Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases. Birth Defects Res C Embryo Today 2010;90(4):243-56. [PubMed Abstract]

Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, Kajita M, Ishizuya-Oka A, Shi YB. Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis. PLoS One 2010;5(10):e13605. [PubMed Abstract]

Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2010. [PubMed Abstract]

Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, Kajita M, Ishizuya-Oka A, Shi YB. Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis. PLoS One 2010;5(10):e13605. [PubMed Abstract]

VanDussen KL, Samuelson LC. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol 2010;346(2):215-23. [PubMed Abstract]

Wang, Z.; Matsudaira, P.; Gong, Z. STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts. PLoS One 5(11):e14063; 2010. [PubMed Abstract]

Yu T, Chen QK, Gong Y, Xia ZS, Royal CR, Huang KH. Higher expression patterns of the intestinal stem cell markers Musashi-1 and hairy and enhancer of split 1 and their correspondence with proliferation patterns in the mouse jejunum. Med Sci Monit. Feb 2010;16(2):BR68-74. [PubMed Abstract]