ISCC News

Cincinnati Children’s Hospital CuSTOM will be hosting a “Frontiers in Organoid Medicine Symposium”, October 18-19, 2018

Congratulations to Ysbrand Nusse from Ophir Klein’s lab on his PhD dissertation, April 17, 2018! Cheers on your accomplishments!

The Farmer Family Foundation pledges a $5 million challenge grant to the Center for Stem Cell and Organoid Medicine (CuSTOM) for the advancement of pioneering research being conducted at Cincinnati Children’s Hospital. ISCC SC Members Michael Helmrath and Jim Wells help lead the groundbreaking research as Associate Director of Clinical Translation and Chief Scientific Officer respectively.

Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISCtargeted damage is increasingly understood, injuryrepair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus i...

Cruz-Acuna R, Quiros M, Farkas AE, Dedhia PH, Huang S, Siuda D, Garcia-Hernandez V, Miller AJ, Spence JR, Nusrat A, Garcia AJ: Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat Cell Biol 2017 Nov, 19(11):1326-1335.

Congratulations to Dr Spence who is now the director of a new initiative, the Translation Tissue Modeling Laboratory (TTML) at the University of Michigan.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling   Highlights   • Satb2 expression marks the presumptive large intestine in frog and mouse embryos • BMP signaling is required for SATB2 expression and activates posterior HOX genes • BMP activation directs hPSC-derived gut tube cultures into colonic organoids (HCOs) • Transplanted HCOs morphologically and molecularly resemble human colon   Click here to view entire ar...

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells   Click here to view entire article.

Nature Medicine (Advance Online Publication) Received 27 July; accepted 14 October; published online 21 November 2016   Researchers from multiple international Universities and at Cincinnati Children’s Hospital Medical Center including ISCC members, James Wells and Michael Helmrath, have published a paper in Nature Medicine titled Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system           Click here to review the entire paper: 

Researchers at Columbia University, including ISCC member Timothy Wang, recently published a paper entitled, “Bone Stem Cells Shown to Regenerate Bone and Cartilage in Adult Mice.”  Dr. Wang said  “Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body’s ability to repair bone injury—a process that declines significantly in old age.”  Previously, Dr. Wang found an analogous stem cell in the intest...