Intestinal stem cells (ISCs) maintain and repair the
intestinal epithelium. While regeneration after ISCtargeted
damage is increasingly understood, injuryrepair
mechanisms that direct regeneration following
injuries to differentiated cells remain uncharacterized.
The enteric pathogen, rotavirus, infects and
damages differentiated cells while sparing all ISC
populations, thus allowing the unique examination
of the response of intact ISC compartments during
injury-repair. Upon rotavirus i...