ISCC News

Congratulations to these young investigators from the Klein Lab who have produced three publications this summer!

Fresh off the Presses! Dr. Jim Wells and other CuSTOM scientists at Cincinnati Children’s work to bioengineer the entire human gastrointestinal system in a laboratory.

Congratulations to Meghan Capeling who recently passed her Biomedical Engineering Ph.D. qualifying exam! Meghan is one of 6 new members of the ISCC Research staff from the Spence lab.

‘New Research Opens Door to Expanding Stem Cells available for Transplants’ was recently announced at Stowers Institute for Medical Research.  The recent research uncovers a new approach for expanding blood-forming, adult stem cells from human umbilical cord blood. This study, by Linheng Li, was published online in Cell Research Read News Article

Congratulations to Jim Wells on his presentation on TEDx Talks on May 12th, 2018 at a TEDx event in Cincinnati. Jim discussed how his team at Cincinnati is using Stem Cells to grow organoids to help diagnose patients and improve care. The CuSTOM team is working to generate lab-grown organs for future transplants.

Cincinnati Children’s Hospital CuSTOM will be hosting a “Frontiers in Organoid Medicine Symposium”, October 18-19, 2018

Congratulations to Ysbrand Nusse from Ophir Klein’s lab on his PhD dissertation, April 17, 2018! Cheers on your accomplishments!

The Farmer Family Foundation pledges a $5 million challenge grant to the Center for Stem Cell and Organoid Medicine (CuSTOM) for the advancement of pioneering research being conducted at Cincinnati Children’s Hospital. ISCC SC Members Michael Helmrath and Jim Wells help lead the groundbreaking research as Associate Director of Clinical Translation and Chief Scientific Officer respectively.

Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISCtargeted damage is increasingly understood, injuryrepair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus i...

Cruz-Acuna R, Quiros M, Farkas AE, Dedhia PH, Huang S, Siuda D, Garcia-Hernandez V, Miller AJ, Spence JR, Nusrat A, Garcia AJ: Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat Cell Biol 2017 Nov, 19(11):1326-1335.