ISCC Publications

Publications Directly Related to the ISCC (116)

This is a list of publications representing the work supported, in part, by funding from the ISCC program. The articles are ordered by year of publication. Items noted with an asterisk (*) do not yet have complete publication attribution.

2017 (31)

Yan, K.S., Janda, C.Y., Chang, J., Zheng, G.X.Y., Larkin, K.A., Luca, V.C., Chia, L.A., Mah, A.T., Han, A., Terry, J.M., Ootani, A., Roelf, K., Lee, M., Yuan, J., Li, X., Bolen, C.R., Wilhelmy, J., Davies, P.S., Ueno, H., von Furstenberg, R.J., Belgrader, P., Ziraldo, S.B., Ordonez, H., Henning, S.J., Wong, M.H., Snyder, M.P., Weissman, I.L., Hsueh, A.J., Mikkelsen, T.S., Garcia, K.C., & Kuo, C.J. (2017). Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature, 545(7653), 238-42. PMID: 28467820. [PubMed Abstract]

Janda, C.Y., Dang, L.T., You, C., Chang, J., de Lau, W., Zhong, Z.A., Yan, K.S., Marecic, O., Siepe, D., Li, X., Moody, J.D., Williams, B.O., Clevers, H., Piehler, J., Baker, D., Kuo, C.J., & Garcia, K.C. (2017). Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature, 545(7653), 234-7. PMID: 28467818. [PubMed Abstract]

Noel, G., Baetz, N.W., Staab, J.F., Donowitz, M., Kovbasnjuk, O., Pasetti, M.F., & Zachos, N.C. (2017). A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Sci Rep, 7, 45270. PMCID: PMC5366908. [PubMed Abstract]

Tsai, Y.H., Nattiv, R., Dedhia, P.H., Nagy, M.S., Chin, A.M., Thomson, M., Klein, O.D., & Spence, J.R. (2017). In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development, 144(6), 1045-55. PMCID: PMC5358103. [PubMed Abstract]

McCauley, H.A., & Wells, J.M. (2017). Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development, 144(6), 958-62. PMCID: PMC5358106. [PubMed Abstract]

Arora, N., Imran Alsous, J., Guggenheim, J.W., Mak, M., Munera, J., Wells, J.M., Kamm, R.D., Asada, H.H., Shvartsman, S.Y., & Griffith, L.G. (2017). A process engineering approach to increase organoid yield. Development, 144(6), 1128-36. PMCID: PMC5358111. [PubMed Abstract]

Nalapareddy, K., Nattamai, K.J., Kumar, R.S., Karns, R., Wikenheiser-Brokamp, K.A., Sampson, L.L., Mahe, M.M., Sundaram, N., Yacyshyn, M.B., Yacyshyn, B., Helmrath, M.A., Zheng, Y., & Geiger, H. (2017). Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell Rep, 18(11), 2608-21. PMID: 28297666. [PubMed Abstract]

Fendler, W., Malachowska, B., Meghani, K., Konstantinopoulos, P.A., Guha, C., Singh, V.K., & Chowdhury, D. (2017). Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med, 9(379). PMCID: PMC5441546. [PubMed Abstract]

Rouch, J.D., & Dunn, J.C. (2017). New insights and interventions for short bowel syndrome. Curr Pediatr Rep, 5(1), 1-5. PMCID: PMC5373550. [PubMed Abstract]

Hill, D.R., & Spence, J.R. (2017). Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface. Cell Mol Gastroenterol Hepatol, 3(2), 138-49. PMCID: PMC5331777. [PubMed Abstract]

Jin, G., Sakitani, K., Wang, H., Jin, Y., Dubeykovskiy, A., Worthley, D.L., Tailor, Y., & Wang, T.C. (2017). The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. Oncotarget, 8(25), 40606-19. PMID: 28380450. [PubMed Abstract]

Tong, J., Tan, S., Nikolovska-Coleska, Z., Yu, J., Zou, F., & Zhang, L. (2017). FBW7-dependent Mcl-1 degradation mediates the anticancer effect of Hsp90 inhibitors. Mol Cancer Ther. PMID: 28619760. [PubMed Abstract]

McCracken, K.W., & Wells, J.M. (2017). Mechanisms of embryonic stomach development. Semin Cell Dev Biol, 66, 36-42. PMCID: PMC5474362. [PubMed Abstract]

Chin, A.M., Hill, D.R., Aurora, M., & Spence, J.R. (2017). Morphogenesis and maturation of the embryonic and postnatal intestine. Semin Cell Dev Biol, 66, 81-93. PMCID: PMC5487846. [PubMed Abstract]

Yan, K.S., Gevaert, O., Zheng, G.X.Y., Anchang, B., Probert, C.S., Larkin, K.A., Davies, P.S., Cheng, Z.F., Kaddis, J.S., Han, A., Roelf, K., Calderon, R.I., Cynn, E., Hu, X., Mandleywala, K., Wilhelmy, J., Grimes, S.M., Corney, D.C., Boutet, S.C., Terry, J.M., Belgrader, P., Ziraldo, S.B., Mikkelsen, T.S., Wang, F., von Furstenberg, R.J., Smith, N.R., Chandrakesan, P., May, R., Chrissy, M.A.S., Jain, R., Cartwright, C.A., Niland, J.C., Hong, Y.K., Carrington, J., Breault, D.T., Epstein, J., Houchen C.W., C.W., Lynch, J.P., Martin, M.G., Plevritis, S.K., Curtis, C., Ji, H.P., Li, L., Henning, S.J., Wong, M.H., & Kuo, C.J. (2017). Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell, 21(1), 78-90 e6. PMID: 28686870. [PubMed Abstract]

Munera, J.O., Sundaram, N., Rankin, S.A., Hill, D., Watson, C., Mahe, M., Vallance, J.E., Shroyer, N.F., Sinagoga, K.L., Zarzoso-Lacoste, A., Hudson, J.R., Howell, J.C., Chatuvedi, P., Spence, J.R., Shannon, J.M., Zorn, A.M., Helmrath, M.A., & Wells, J.M. (2017). Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell, 21(1), 51-64 e6. PMCID: PMC5531599. [PubMed Abstract]

Middelhoff, M., Westphalen, C.B., Hayakawa, Y., Yan, K.S., Gershon, M.D., Wang, T.C., & Quante, M. (2017). Dclk1-expressing tuft cells: Critical modulators of the intestinal niche? Am J Physiol Gastrointest Liver Physiol, ajpgi 00073 2017. PMID: 28684459. [PubMed Abstract]

Jadhav, U., Saxena, M., O'Neill, N.K., Saadatpour, A., Yuan, G.C., Herbert, Z., Murata, K., & Shivdasani, R.A. (2017). Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell, 21(1), 65-77 e5. PMCID: PMC5505276. [PubMed Abstract]

Brodin, N.P., Velcich, A., Guha, C., & Tome, W.A. (2017). A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems. Dose Response, 15(1), 1559325816685798. PMCID: PMC5298432. [PubMed Abstract]

McCracken, K.W., Aihara, E., Martin, B., Crawford, C.M., Broda, T., Treguier, J., Zhang, X., Shannon, J.M., Montrose, M.H., & Wells, J.M. (2017). Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature, 541(7636), 182-7. PMCID: PMC5526592. [PubMed Abstract]

Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B.W., Tailor, Y., Macchini, M., Middelhoff, M., Jiang, Z., Tanaka, T., Dubeykovskaya, Z.A., Kim, W., Chen, X., Urbanska, A.M., Nagar, K., Westphalen, C.B., Quante, M., Lin, C.S., Gershon, M.D., Hara, A., Zhao, C.M., Chen, D., Worthley, D.L., Koike, K., & Wang, T.C. (2017). Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell, 31(1), 21-34. PMCID: PMC5225031. [PubMed Abstract]

Blutt, S.E., Broughman, J.R., Zou, W., Zeng, X.L., Karandikar, U.C., In, J., Zachos, N.C., Kovbasnjuk, O., Donowitz, M., & Estes, M.K. (2017). Gastrointestinal microphysiological systems. Exp Biol Med (Maywood), 1535370217710638. PMID: 28534432. [PubMed Abstract]

Workman, M.J., Mahe, M.M., Trisno, S., Poling, H.M., Watson, C.L., Sundaram, N., Chang, C.F., Schiesser, J., Aubert, P., Stanley, E.G., Elefanty, A.G., Miyaoka, Y., Mandegar, M.A., Conklin, B.R., Neunlist, M., Brugmann, S.A., Helmrath, M.A., & Wells, J.M. (2017). Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med, 23(1), 49-59. PMID: 27869805. [PubMed Abstract]

Lo, Y.H., Chung, E., Li, Z., Wan, Y.W., Mahe, M.M., Chen, M.S., Noah, T.K., Bell, K.N., Yalamanchili, H.K., Klisch, T.J., Liu, Z., Park, J.S., & Shroyer, N.F. (2017). Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. Cell Mol Gastroenterol Hepatol, 3(1), 51-71. PMCID: PMC5247424. [PubMed Abstract]

Tong, J., Wang, P., Tan, S., Chen, D., Nikolovska-Coleska, Z., Zou, F., Yu, J., & Zhang, L. (2017). Mcl-1 degradation is required for targeted therapeutics to eradicate colon cancer cells. Cancer Res. PMID: 28202514. [PubMed Abstract]

Yu, H., Hasan, N.M., In, J.G., Estes, M.K., Kovbasnjuk, O., Zachos, N.C., & Donowitz, M. (2017). The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol, 79, 291-312. PMID: 28192061. [PubMed Abstract]

Chandrakesan, P., Yao, J., Qu, D., May, R., Weygant, N., Ge, Y., Ali, N., Sureban, S.M., Gude, M., Vega, K., Bannerman-Menson, E., Xia, L., Bronze, M., An, G., & Houchen C.W. (2017). Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer, 16(1), 30. PMCID: PMCPMC5286867. [PubMed Abstract]

Hong, S.N., Dunn, J.C., Stelzner, M., & Martin, M.G. (2017). Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure. Stem Cells Transl Med, 6(2), 666-76. PMCID: PMC5442796. [PubMed Abstract]

Tadesse, S., Corner, G., Dhima, E., Houston, M., Guha, C., Augenlicht, L., & Velcich, A. (2017). MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa. Oncotarget. PMID: 28431399. [PubMed Abstract]

Munera, J.O., & Wells, J.M. (2017). Generation of Gastrointestinal Organoids from Human Pluripotent Stem Cells. Methods Mol Biol, 1597, 167-77. PMID: 28361317. [PubMed Abstract]

Mahe, M.M., Brown, N.E., Poling, H.M., & Helmrath, M.A. (2017). In Vivo Model of Small Intestine. Methods Mol Biol, 1597, 229-45. PMID: 28361322. [PubMed Abstract]

2016 (24)

Sailaja, B.S., He, X.C., & Li, L. (2016). The regulatory niche of intestinal stem cells. J Physiol, 594(17), 4827-36. PMCID: PMC5009778. [PubMed Abstract]

Mah, A.T., Yan, K.S., & Kuo, C.J. (2016). Wnt pathway regulation of intestinal stem cells. J Physiol, 594(17), 4837-47. PMCID: PMC5009769. [PubMed Abstract]

Tsai, Y.H., Hill, D.R., Kumar, N., Huang, S., Chin, A.M., Dye, B.R., Nagy, M.S., Verzi, M.P., & Spence, J.R. (2016). LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation. Cell Mol Gastroenterol Hepatol, 2(5), 648-62 e8. PMCID: PMC5042889. [PubMed Abstract]

Soffers, J.H., Hansen, D., Sinagoga, K.L., Li, B., Martin, M.G., Wells, J. , Grompe, M., & Li, L. (2016). Stem Cells and Regeneration in the Digestive System: Keystone Meeting. Gastroenterology, 151(3), e6-9. PMID: 27480172. [PubMed Abstract]

Saha, S., Aranda, E., Hayakawa, Y., Bhanja, P., Atay, S., Brodin, N.P., Li, J., Asfaha, S., Liu, L., Tailor, Y., Zhang, J., Godwin, A.K., Tome, W.A., Wang, T.C., Guha, C., & Pollard, J.W. (2016). Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. Nat Commun, 7, 13096. PMCID: PMC5065628. [PubMed Abstract]

Chin, A.M., Tsai, Y.H., Finkbeiner, S.R., Nagy, M.S., Walker, E.M., Ethen, N.J., Williams, B.O., Battle, M.A., & Spence, J.R. (2016). A Dynamic WNT/beta-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. Stem Cell Reports, 7(5), 826-39. PMCID: PMC5106483. [PubMed Abstract]

Kulkarni, S., Koller, A., Mani, K.M., Wen, R., Alfieri, A., Saha, S., Wang, J., Patel, P., Bandeira, N., Guha, C., & Chen, E.I. (2016). Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow. Int J Radiat Oncol Biol Phys, 96(3), 566-77. PMCID: PMC5042854. [PubMed Abstract]

In, J.G., Foulke-Abel, J., Estes, M.K., Zachos, N.C., Kovbasnjuk, O., & Donowitz, M. (2016). Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol, 13(11), 633-42. PMCID: PMC5079760. [PubMed Abstract]

Neal, J.T., & Kuo, C.J. (2016). Organoids as Models for Neoplastic Transformation. Annu Rev Pathol, 11, 199-220. PMID: 26907527. [PubMed Abstract]

Dedhia, P.H., Bertaux-Skeirik, N., Zavros, Y., & Spence, J.R. (2016). Organoid Models of Human Gastrointestinal Development and Disease. Gastroenterology, 150(5), 1098-112. PMCID: PMC4842135. [PubMed Abstract]

Mah, A.T., & Kuo, C.J. (2016). Home Sweet Home: a Foxl1+ Mesenchymal Niche for Intestinal Stem Cells. Cell Mol Gastroenterol Hepatol, 2(2), 116-7. PMCID: PMC4980738. [PubMed Abstract]

Jadhav, U., Nalapareddy, K., Saxena, M., O'Neill, N.K., Pinello, L., Yuan, G.C., Orkin, S.H., & Shivdasani, R.A. (2016). Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell, 165(6), 1389-400. PMCID: PMC4893000. [PubMed Abstract]

Scott, A., Rouch, J.D., Jabaji, Z., Khalil, H.A., Solorzano, S., Lewis, M., Martin, M.G., Stelzner, M.G., & Dunn, J.C. (2016). Long-term renewable human intestinal epithelial stem cells as monolayers: A potential for clinical use. J Pediatr Surg, 51(6), 995-1000. PMCID: PMC4921284. [PubMed Abstract]

Belinson, H., Savage, A.K., Fadrosh, D., Kuo, Y.M., Lin, D., Valladares, R., Nusse, Y., Wynshaw-Boris, A., Lynch, S.V., Locksley, R.M., & Klein, O.D.(2016). Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight, 1(10). PMCID: PMC4979554. [PubMed Abstract]

Khalil, H.A., Lei, N.Y., Brinkley, G., Scott, A., Wang, J., Kar, U.K., Jabaji, Z.B., Lewis, M., Martin, M.G., Dunn, J.C., & Stelzner, M.G. (2016). A novel culture system for adult porcine intestinal crypts. Cell Tissue Res, 365(1), 123-34. PMCID: PMCPMC4919165. [PubMed Abstract]

Dubeykovskaya, Z., Si, Y., Chen, X., Worthley, D.L., Renz, B.W., Urbanska, A.M., Hayakawa, Y., Xu, T., Westphalen, C.B., Dubeykovskiy, A., Chen, D., Friedman, R.A., Asfaha, S., Nagar, K., Tailor, Y., Muthupalani, S., Fox, J.G., Kitajewski, J., & Wang, T.C. (2016). Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nat Commun, 7, 10517. PMCID: PMC4742920. [PubMed Abstract]

Wells, J.M. (2016). Regenerative medicine in 2015: Generating and regenerating the digestive system. Nat Rev Gastroenterol Hepatol, 13(2), 65-6. PMID: 26758784. [PubMed Abstract]

Aurora, M., & Spence, J.R. (2016). hPSC-derived lung and intestinal organoids as models of human fetal tissue. Dev Biol, 420(2), 230-8. PMCID: PMC5140713. [PubMed Abstract]

Kulkarni, S., Wang, T.C., & Guha, C. (2016). Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries. Curr Pathobiol Rep, 4(4), 221-30. PMCID: PMC5409531. [PubMed Abstract]

Kim, T.H., Saadatpour, A., Guo, G., Saxena, M., Cavazza, A., Desai, N., Jadhav, U., Jiang, L., Rivera, M.N., Orkin, S.H., Yuan, G.C., & Shivdasani, R.A. (2016). Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep, 16(8), 2053-60. PMCID: PMC5001892. [PubMed Abstract]

Wang, Y., Wang, X., Flores, E.R., Yu, J., & Chang, S. (2016). Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell. PMID: 27113195. [PubMed Abstract]

Chandrakesan, P., Panneerselvam, J., Qu, D., Weygant, N., May, R., Bronze, M.S., & Houchen C.W. (2016). Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells. J Carcinog Mutagen, 7(2). PMCID: PMCPMC4913783. [PubMed Abstract]

Westphalen, C.B., Middelhoff, M., Quante, M., & Wang, T.C. (2016). Epithelial Dclk1+ cells are not neural crest derived. Stem Cell Investig, 3, 60. PMCID: PMC5104577. [PubMed Abstract]

Rouch, J.D., Scott, A., Lei, N.Y., Solorzano-Vargas, R.S., Wang, J., Hanson, E.M., Kobayashi, M., Lewis, M., Stelzner, M.G., Dunn, J.C., Eckmann, L., & Martin, M.G. (2016). Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. PLoS One, 11(1), e0148216. PMCID: PMC4731053. [PubMed Abstract]

2015 (26)

Manieri, N.A., Mack, M.R., Himmelrich, M.D., Worthley, D.L., Hanson, E.M., Eckmann, L., Wang, T.C., & Stappenbeck, T.S. (2015). Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. J Clin Invest, 125(9), 3606-18. PMCID: PMC4588308. [PubMed Abstract]

DiMarco, R.L., Dewi, R.E., Bernal, G., Kuo, C., & Heilshorn, S.C. (2015). Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids. Biomater Sci, 3(10), 1376-85. PMID: 26371971. [PubMed Abstract]

Chandrakesan, P., May, R., Qu, D., Weygant, N., Taylor, V.E., Li, J.D., Ali, N., Sureban, S.M., Qante, M., Wang, T.C., Bronze, M.S., & Houchen C.W. (2015). Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal. Oncotarget, 6(31), 30876-86. PMCID: PMC4741574. [PubMed Abstract]

Finkbeiner, S.R., Freeman, J.J., Wieck, M.M., El-Nachef, W., Altheim, C.H., Tsai, Y.H., Huang, S., Dyal, R., White, E.S., Grikscheit, T.C., Teitelbaum, D.H., & Spence, J.R. (2015). Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids. Biol Open, 4(11), 1462-72. PMCID: PMC4728347. [PubMed Abstract]

Acharya, S.S., Fendler, W., Watson, J., Hamilton, A., Pan, Y., Gaudiano, E., Moskwa, P., Bhanja, P., Saha, S., Guha, C., Parmar, K., & Chowdhury, D. (2015). Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury. Sci Transl Med, 7(287), 287ra69. PMCID: PMC4686271. [PubMed Abstract]

Sinagoga, K.L., & Wells, J.M. (2015). Generating human intestinal tissues from pluripotent stem cells to study development and disease. EMBO J, 34(9), 1149-63. PMCID: PMC4426477. [PubMed Abstract]

McGrath, P.S., & Wells, J.M. (2015). SnapShot: GI tract development. Cell, 161(1), 176- e1. PMID: 25815994. [PubMed Abstract]

Wells, J.M. (2015). Developmental biology. Regional identity of gut stem cells--one gene to rule them all. Nat Rev Gastroenterol Hepatol, 12(3), 125-6. PMID: 25645971. [PubMed Abstract]

Gracz, A.D., Williamson, I.A., Roche, K.C., Johnston, M.J., Wang, F., Wang, Y., Attayek, P.J., Balowski, J., Liu, X.F., Laurenza, R.J., Gaynor, L.T., Sims, C.E., Galanko, J.A., Li, L., Allbritton, N.L., & Magness, S.T. (2015). A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis. Nat Cell Biol, 17(3), 340-9. PMCID: PMC4405128. [PubMed Abstract]

Goldman, D.C., Alexeev, V., Lash, E., Guha, C., Rodeck, U., & Fleming, W.H. (2015). The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Radiat Res, 183(3), 338-44. PMID: 25738896. [PubMed Abstract]

Asfaha, S., Hayakawa, Y., Muley, A., Stokes, S., Graham, T.A., Ericksen, R.E., Westphalen, C.B., von Burstin, J., Mastracci, T.L., Worthley, D.L., Guha, C., Quante, M., Rustgi, A.K., & Wang, T.C. (2015). Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell Stem Cell, 16(6), 627-38. PMCID: PMCPMC4457942. [PubMed Abstract]

Finkbeiner, S.R., Hill, D.R., Altheim, C.H., Dedhia, P.H., Taylor, M.J., Tsai, Y.H., Chin, A.M., Mahe, M.M., Watson, C.L., Freeman, J.J., Nattiv, R., Thomson, M., Klein, O.D., Shroyer, N.F., Helmrath, M.A., Teitelbaum, D.H., Dempsey, P.J., & Spence, J.R. (2015). Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. PMCID: PMC4471827. [PubMed Abstract]

Van Landeghem, L., Santoro, M.A., Mah, A.T., Krebs, A.E., Dehmer, J.J., McNaughton, K.K., Helmrath, M.A., Magness, S.T., & Lund, P.K. (2015). IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J, 29(7), 2828-42. PMCID: PMC4478798. [PubMed Abstract]

Worthley, D.L., Churchill, M., Compton, J.T., Tailor, Y., Rao, M., Si, Y., Levin, D., Schwartz, M.G., Uygur, A., Hayakawa, Y., Gross, S., Renz, B.W., Setlik, W., Martinez, A.N., Chen, X., Nizami, S., Lee, H.G., Kang, H.P., Caldwell, J.M., Asfaha, S., Westphalen, C.B., Graham, T., Jin, G., Nagar, K., Wang, H., Kheirbek, M.A., Kolhe, A., Carpenter, J., Glaire, M., Nair, A., Renders, S., Manieri, N., Muthupalani, S., Fox, J.G., Reichert, M., Giraud, A.S., Schwabe, R.F., Pradere, J.P., Walton, K., Prakash, A., Gumucio, D., Rustgi, A.K., Stappenbeck, T.S., Friedman, R.A., Gershon, M.D., Sims, P., Grikscheit, T., Lee, F.Y., Karsenty, G., Mukherjee, S., & Wang, T.C. (2015). Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell, 160(1-2), 269-84. PMCID: PMC4436082. [PubMed Abstract]

Yan, K.S., & Kuo, C.J. (2015). Ascl2 reinforces intestinal stem cell identity. Cell Stem Cell, 16(2), 105-6. PMID: 25658363. [PubMed Abstract]

P, O. Broin, Vaitheesvaran, B., Saha, S., Hartil, K., Chen, E.I., Goldman, D., Fleming, W.H., Kurland, I.J., Guha, C., & Golden, A. (2015). Intestinal microbiota-derived metabolomic blood plasma markers for prior radiation injury. Int J Radiat Oncol Biol Phys, 91(2), 360-7. PMCID: PMC4312583. [PubMed Abstract]

Lindemans, C.A., Calafiore, M., Mertelsmann, A.M., O'Connor, M.H., Dudakov, J.A., Jenq, R.R., Velardi, E., Young, L.F., Smith, O.M., Lawrence, G., Ivanov, J.A., Fu, Y.Y., Takashima, S., Hua, G., Martin, M.L., O'Rourke, K.P., Lo, Y.H., Mokry, M., Romera-Hernandez, M., Cupedo, T., Dow, L., Nieuwenhuis, E.E., Shroyer, N.F., Liu, C., Kolesnick, R., van den Brink, M.R.M., & Hanash, A.M. (2015). Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature, 528(7583), 560-4. PMCID: PMC4720437. [PubMed Abstract]

Gross, S., Balderes, D., Liu, J., Asfaha, S., Gu, G., Wang, T.C., & Sussel, L. (2015). Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol, 309(12), G975-87. PMCID: PMC4683302. [PubMed Abstract]

Hayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B.W., Dubeykovskaya, Z.A., Shibata, W., Wang, H., Westphalen, C.B., Chen, X., Takemoto, Y., Kim, W., Khurana, S.S., Tailor, Y., Nagar, K., Tomita, H., Hara, A., Sepulveda, A.R., Setlik, W., Gershon, M.D., Saha, S., Ding, L., Shen, Z., Fox, J.G., Friedman, R.A., Konieczny, S.F., Worthley, D.L., Korinek, V., & Wang, T.C. (2015). Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell, 28(6), 800-14. PMCID: PMC4684751. [PubMed Abstract]

Asfaha, S. (2015). Intestinal stem cells and inflammation. Curr Opin Pharmacol, 25, 62-6. PMID: 26654865. [PubMed Abstract]

Schumacher, M.A., Aihara, E., Feng, R., Engevik, A., Shroyer, N.F., Ottemann, K.M., Worrell, R.T., Montrose, M.H., Shivdasani, R.A., & Zavros, Y. (2015). The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol, 593(8), 1809-27. PMCID: PMC4405744. [PubMed Abstract]

Wang, X., Wei, L., Cramer, J.M., Leibowitz, B.J., Judge, C., Epperly, M., Greenberger, J., Wang, F., Li, L., Stelzner, M.G., Dunn, J.C., Martin, M.G., Lagasse, E., Zhang, L., & Yu, J. (2015). Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep, 5, 8566. PMCID: PMC4392360. [PubMed Abstract]

Tian, H., Biehs, B., Chiu, C., Siebel, C.W., Wu, Y., Costa, M., de Sauvage, F.J., & Klein, O.D.(2015). Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep, 11(1), 33-42. PMCID: PMC4394041. [PubMed Abstract]

Qu, D., Weygant, N., May, R., Chandrakesan, P., Madhoun, M., Ali, N., Sureban, S.M., An, G., Schlosser, M.J., & Houchen C.W. (2015). Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PLoS One, 10(8), e0134212. PMCID: PMC4540568. [PubMed Abstract]

Khalil, H.A., Lei, N.Y., Nie, W., Lewis, M.S., Stelzner, M.G., Martin, M.G., Dunn, J.C., & Yoo, J. (2015). Primary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy. PLoS One, 10(5), e0127258. PMCID: PMC4445916. [PubMed Abstract]

Hamilton, K.E., Crissey, M.A., Lynch, J.P., & Rustgi, A.K.(2015). Culturing adult stem cells from mouse small intestinal crypts. Cold Spring Harb Protoc, 2015(4), pdb prot078303. PMID: 25834260.

Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW. DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition. Oncotarget. Oct 15 2014;5(19):9269-9280.[PubMed Abstract]

Jabaji Z, Brinkley GJ, Khalil HA, Sears CM, Lei NY, Lewis M, Stelzner M, Martin MG, Dunn JC. Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium. PLoS One. 2014;9(9):e107814. [PubMed Abstract]

Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2014;306(5):G404-411. [PubMed Abstract]

2013 (11)

Barry ER, Morikawa T, Butler BL, Shrestha K, Fuchs CS, de la Rosa, Yan KS, Magness ST, Ogino S, Kuo CJ, and Camargo FD. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013 Jan 3; 493(7430):106-10. [PubMed Abstract]

*Dimarco RL, Su J, Yan KS, Dewi R, Kuo CJ, Heilshorn SC 2013 Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. Integrative biology [PubMed Abstract]

*Gracz AD, Fuller MK, Wang F, Li L, Stelzner M, Dunn JC, Martin MG, Magness ST. CD24 and CD44 Mark Human Intestinal Epithelial Cell Populations with Characteristics of Active and Facultative Stem Cells. Stem cells 2013 Apr 4. [PubMed Abstract]

*Jabaji Z, Sears CM, Brinkley GJ, et al. Use of Collagen Gel As an Alternative Extracellular Matrix for the In Vitro and In Vivo Growth of Murine Small Intestinal Epithelium. Tissue engineering. Part C, Methods. May 10 2013. [PubMed Abstract]

*Magness ST, Puthoff BJ, Crissey MA, Dunn JC, Henning SJ, Houchen CW, Kaddis JS, Kuo CJ, Li L, Lynch JP, Martin MG, May RJ, Niland JC, Olack B, Qian D, Stelzner M, Swain J, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH 2013 A multi-center study to standardize reporting and analyses of fluorescence-activated cell sorted murine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol [PubMed Abstract]

*May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Li L, Sureban SM, Houchen CW 2013 Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury. Stem cells (Dayton, Ohio) [PubMed Abstract]

Qiu W, Wang X, Buchanan M, et al. ADAR1 is essential for intestinal homeostasis and stem cell maintenance. Cell death & disease. 2013;4:e599. [PubMed Abstract]

*Qu D, May RJ, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett TA, Houchen CW 2013 Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury. Am J Physiol Gastrointest Liver Physiol [PubMed Abstract]

von Furstenberg RJ, Buczacki SJ, Smith BJ, Seiler KM, Winton DJ, Henning SJ 2013 Side population sorting separates subfractions of cycling and non-cycling intestinal stem cells. Stem cell research 12:364-375 [PubMed Abstract]

*Wang F, Scoville D, He XC, et al. Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay. Gastroenterology. May 2 2013. [PubMed Abstract]

*Yu J 2013 Intestinal stem cell injury and protection during cancer therapy. Translational Cancer Research. [Abstract]

2012 (7)

Fuller, M. K.; Faulk, D. M.; Sundaram, N.; Shroyer, N. F.; Henning, S. J.; Helmrath, M. A. Intestinal crypts reproducibly expand in culture. J Surg Res, 2012 Nov; 178(1): 48-54. [PubMed Abstract]

Gulati AS, Shanahan MT, Arthur JC, Grossniklaus E, von Furstenberg RJ, Kreuk L, Henning SJ, Jobin C, Sartor RB. Mouse background strain profoundly influences paneth cell function and intestinal microbial composition. PLoS One 2012;7(2):e32403. [PubMed Abstract]

King JB, von Furstenberg RJ, Smith BJ, McNaughton KK, Galanko JA, Henning SJ. CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice. Am J Physiol Gastrointest Liver Physiol, 2012 Aug 15; 303(4): G443-52. [PubMed Abstract]

Stelzner M, Helmrath MA, Dunn JC, Henning SJ, Houchen CW, Kuo CJ, Lynch JP, Li L, Martin MG, Wong MH, Yu J. A Nomenclature for Intestinal In Vitro Cultures. Am J Physiol Gastrointest Liver Physiol, 2012 Jun 15; 302(12): G1359-63. [PubMed Abstract]

Van Landeghem L, Blue RE, Dehmer JJ, Henning SJ, Helmrath MA, Lund PK. Localized intestinal radiation and liquid diet enhance survivial and permit evaluation of long-term intestinal responses to high dose radiation in mice. PloS One, 2012; 7(12):e51310. [PubMed Abstract]

Vega KJ, May R, Sureban SM, Lightfoot SA, Qu D, Reed A, Weygant N, Ramanujam R, Souza R, Madhoun M, Whorton J, Anant S, Meltzer S, Houchen CW. Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma. J Gastroenterol Hepatol 2012 Apr;27(4):773-80. [PubMed Abstract]

Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci U S A, 2012 Jan 10; 109(2): 466-71.[PubMed Abstract]

2011 (10)

Crissey MA, Guo RJ, Funakoshi S, Kong J, Liu J, Lynch JP. Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology 2011 Feb; 140(2):517-528 e8. [PubMed Abstract]

Dehmer JJ, Garrison AP, Speck KE, Dekaney CM, Van Landeghem L, Sun X, Henning SJ, Helmrath MA. Expansion of Intestinal Epithelial Stem Cells during Murine Development. PLoS One 2011;6(11):e27070. [PubMed Abstract]

Gracz AD, Magness ST. Sry-box (SOX) transcription factors in gastrointestinal physiology and disease. Am J Physiol Gastrointest Liver Physiol 2011 Apr;300(4):G503-15. [PubMed Abstract]

Lahar N, Lei NY, Wang J, Jabaji Z, Tung SC, Joshi V, Lewis M, Stelzner M, Martin MG, Dunn JC. Intestinal Subepithelial Myofibroblasts Support in vitro and in vivo Growth of Human Small Intestinal Epithelium. PLoS One 2011;6(11):e26898. [PubMed Abstract]

Leibowitz B, Qiu W, Liu H, Cheng T, Zhang L, Yu J. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res 2011May; 9(5):616-25. [PubMed Abstract]

Mustata G, Li M, Zevola N, Bakan A, Zhang L, Epperly M, Greenberger JS, Yu J, Bahar I. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Top Med Chem 2011;11(3):281-90. [PubMed Abstract]

Qiu W, Wang X, Leibowitz B, Yang W, Zhang L, Yu J. PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology 2011 Oct;54(4):1249-58. [PubMed Abstract]

Sureban SM, May R, Mondalek FG, Qu D, Ponnurangam S, Pantazis P, Anant S, Ramanujam RP, Houchen CW. Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology 2011 Sep 19;9(1):40. [PubMed Abstract]

von Furstenberg, R. J.; Gulati, A. S.; Baxi, A.; Doherty, J. M.; Stappenbeck, T. S.; Gracz, A. D.; Magness, S. T.; Henning, S. J. Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells. Am J Physiol Gastrointest Liver Physiol 2011 Mar;300(3):G409-417; 2011.[PubMed Abstract]

Yeung, T. M.; Chia, L. A.; Kosinski, C. M.; Kuo, C. J. Regulation of self-renewal and differentiation by the intestinal stem cell niche. Cell Mol Life Sci; 2011 Aug; 68(15):2513-23. [PubMed Abstract]

2010 (4)

Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH. Characterization of the intestinal cancer stem cell marker, CD166/ALCAM, in the human and mouse gastrointestinal tract. Gastroenterology, 2010 Dec;139(6):2072-2082.e5. [PubMed Abstract]

Li L, Clevers H. Coexistence of Quiescent and Active Adult Stem Cells in Mammals, Science. 2010 Jan 29;327(5965):542-5. [PubMed Abstract]

Qiu W, Leibowitz B, Zhang L, Yu J. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene. 2010 Mar 18;29(11):1622-1632. [PubMed Abstract]

Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J, Zhang L. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci U S A 2010 Nov 16;107(46):20027-32. [PubMed Abstract]

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Additional Publications from ISCC Support (25)

2017 (2)

Kim GA, Spence JR, Takayama S 2017 Bioengineering for intestinal organoid cultures. Current Opinion in Biotechnology. 2017 Jun 21; 47:51-58 [PubMed Abstract]

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Jr., Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA 2017 A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jun; 153:e6-e13 [PubMed Abstract]

2016 (3)

Jadhav U, Shivdasani RA 2016 Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cellular and Molecular Gastroenterology and Hepatology 2016 Sep 26;2(6):714-715 [PubMed Abstract]

Mah AT, Yan KS, Kuo CJ 2016 Wnt pathway regulation of intestinal stem cells. The Journal of physiology 2016 Sep 1;594(17):4837-4847 [PubMed Abstract]

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K 2016 Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell reports 2016 Aug 16;16 (7):1929-1941 [PubMed Abstract]

2015 (2)

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M 2015 Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology 2015 Dec 8. pii: S0016-5085(15)01733-3. doi: 10.1053/j.gastro.2015.11.047. [Epubahead of print] [PubMed Abstract]

Sailaja BS, He XC, Li L 2015 Stem Cells Matter in Response to Fasting. Cell Reports 2015 Dec 22;13(11):2325-6. doi: 10.1016/j.celrep.2015.12.008. [PubMed Abstract]

2014 (3)

*Hartman KG, Bortner JD, Jr., Falk GW, Ginsberg GG, Jhala N, Yu J, Martin MG, Rustgi AK, Lynch JP. Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Experimental biology and medicine . 2014 [PubMed Abstract]

Leibowitz B, Qiu W, Buchanan ME, Zou F, Vernon P, Moyer MP, Yin XM, Schoen RE, Yu J, Zhang L. BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. Nov 18 2014;111(46):16520-16525. [PubMed Abstract]

Leibowitz BJ, Wei L, Zhang L, Ping X, Epperly M, Greenberger J, Cheng T, Yu J 2014 Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nature communications 5:3494 [PubMed Abstract]

2013 (3)

Dimarco RL, Su J, Yan KS, Dewi R, Kuo CJ, Heilshorn SC 2013 Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. Integrative biology : quantitative biosciences from nano to macro [PubMed Abstract]

Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R 2013 Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342:1226-1230 [PubMed Abstract]

Shanahan MT, Carroll IM, Grossniklaus E, White A, von Furstenberg RJ, Barner R, Fodor AA, Henning SJ, Sartor RB, Gulati AS 2013 Mouse Paneth cell antimicrobial function is independent of Nod2. Gut 2013 Mar 19.[PubMed Abstract]

2012 (4)

Fan X, Krieg S, Hwang JY, Dhal S, Kuo CJ, Lasley BL, Brenner RM, Nayak NR. Dynamic Regulation of Wnt7a Expression in the Primate Endometrium: Implications for Postmenstrual Regeneration and Secretory Transformation. Endocrinology 2012 Mar;153(3):1063-9.. [PubMed Abstract]

Rosenbluh, J, Nijhawan D, Cox A, Li X, Neal, JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC. ß-catenin driven cancers require a YAP1 transcriptional regulatory complex for survival and tumorigenesis. Cell, 2012 Dec 21;151(7):1457-73. [PubMed Abstract]

*Zhang L, Yu J 2013 Role of apoptosis in colon cancer biology, therapy, and prevention. Current colorectal cancer reports 9 [PubMed Abstract]

Qiu W, Liu H, Sebastini A, Sun Q, Wang H, Zhang L, Yu J. An apoptosis-independent role of SMAC in tumor suppression. Oncogene 2012 Jul 2. doi: 10.1038/onc.2012.265. [PubMed Abstract]

2011 (6)

Ali N, Allam H, May R, Sureban SM, Bronze MS, Bader T, Umar S, Anant S, Houchen CW. Hepatitis C Virus-Induced Cancer Stem Cell-like Signatures in Cell Culture and Murine Tumor Xenografts. J Virol 2011 Dec;85(23):12292-303. [PubMed Abstract]

King CE, Wang L, Winograd R, Madison BB, Mongroo PS, Johnstone CN, Rustgi AK. LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. Oncogene 2011. [PubMed Abstract]

Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Beer-Stolz D, Yu J, Zhang L. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase-8-mediated cleavage of Beclin-1. Cancer Res 2011 May 15;71(10):3625-34. [PubMed Abstract]

Li H, Wang P, Yu J, Zhang L. Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis. Autophagy 2011 Oct;7(10):1239-41. [PubMed Abstract]

Qiu W, Wu B, Wang X, Buchanan ME, Regueiro MD, Hartman DJ, Schoen RE, Yu J, Zhang L. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest 2011 May;121(5):1722-32. [PubMed Abstract]

Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D'Agati VD, Artandi SE. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med 2011 Dec 4;18(1):111-9. [PubMed Abstract]

2010 (2)

Leibowitz B, Yu J. Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther. 2010 Mar 15;9(6):417-422.[PubMed Abstract]

Yu H, Shen H, Yuan Y, et al. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood. 2010 Apr 29;115(17):3472-3480. [PubMed Abstract]