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ISCC Publications

Publications from ISCC Support (175)

This is a list of publications representing the work supported by funding from the ISCC program. The articles are ordered by year of publication. Authors names that are in bold represent past or present ISCC Investigators.
Santos AJM, Lo YH, Mah AT, Kuo CJ. 1. Santos AJM, Lo YH, Mah AT, Kuo CJ. The Intestinal Stem Cell Niche: Homeostasis and Adaptations. Trends Cell Biol, 2018 Sep.

Srivillibhuthur M, Warder BN, Toke NH, Shah PP, Feng Q, Gao N, Bonder EM, Verzi MP: TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol 2018 Jul, 439(2):92-101.

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature 2018 Jul, 559(7712):109-113

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM. Mechanically induced development and maturation of human intestinal organoids in vivo. Nat Biomed Eng, 2018 Jun, 2(6): 429-42. PMCID: 6108544.

Rankin CR, Theodorou E, Law IKM, Rowe L, Kokkotou E, Pekow J, Wang J, Martin MG, Pothoulakis C, Padua DM: Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2018 Jun.

McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD: Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife 2018 Jun.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martin MG, Pedi CC: Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 2018 Jun, 154(8):2045-2059 e2046.

Smith NR, Swain JR, Davies PS, Gallagher AC, Parappilly MS, Beach CZ, Streeter PR, Williamson IA, Magness ST, Wong MH. Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations. Cell Mol Gastroenterol Hepatol, 2018 Jun, 6(1): 79-96. PMCID: 6008251.

Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L: Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene 2018 May.

Wang Q, Wang K, Solorzano-Vargas RS, Lin PY, Walthers CM, Thomas AL, Martin MG, Dunn JCY: Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractions. PLoS One 2018 May, 13(5):e0195315.

Kuo CJ, Curtis C. Organoids reveal cancer dynamics. Nature, 2018 Apr, 556(7702): 441-2.

Spence JR: Taming the Wild West of Organoids, Enteroids, and Mini-Guts. Cell Mol Gastroenterol Hepatol 2018 Apr, 5(2):159-160.

Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L: PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci USA 2018 Apr, 115(15):3930-3935.

Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L: Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta 2018 Apr, 1869(2):138-148.

Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK: Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol 2018 Mar, 5(3):241-251.

Rankin SA, McCracken KW, Luedeke DM, Han L, Wells JM, Shannon JM, Zorn AM: Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis. Dev Biol 2018 Feb, 434(1):121-132.

Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martin MG, Alrefai WA, Ford DA, Tontonoz P: Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 2018 Feb, 22(2):206-220 e204.

Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD , Shroyer NF , Donowitz M , Estes MK: Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep 2018 Jan, 22(4):1003-1015.
Tong K, Pellon-Cardenas O, Sirihorachai VR, Warder BN, Kothari OA, Perekatt AO, Fokas EE, Fullem RL, Zhou A, Thackray JK, Tran H, Zhang L, Xing J, Verzi MP: Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. Cell Rep 2017 Dec, 21(13):3833-3845.

Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martin MG, Allenspach K: Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research. AAPS J 2017 Dec, 20(1):17.

Cruz-Acuna R, Quiros M, Farkas AE, Dedhia PH, Huang S, Siuda D, Garcia-Hernandez V, Miller AJ, Spence JR, Nusrat A, Garcia AJ: Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat Cell Biol 2017 Nov, 19(11):1326-1335.

Hill DR, Huang S, Nagy MS, Yadagiri VK, Fields C, Mukherjee D, Bons B, Dedhia PH, Chin AM, Tsai YH, Thodla S, Schmidt TM, Walk S, Young VB, Spence JR: Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. Elife 2017 Nov, 6.

Yousefi M, Li L, Lengner CJ: Hierarchy and Plasticity in the Intestinal Stem Cell Compartment. Trends Cell Biol 2017 Oct, 27(10):753-764.

Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L : FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther 2017 Sep, 16(9):1979-1988.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A: Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.J Clin Invest 2017 Sep, 127(9):3510-3520.

Moorefield EC, Andres SF, Blue RE, Van Landeghem L, Mah AT, Santoro MA, Ding S: Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells. Aging (Albany NY) 2017 Aug, 9(8):1898-1915.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Jr., Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA: A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology 2017 Jul, 153(1):e6-e13.

Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA : Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell 2017 Jul, 21(1):65-77 e65.

Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC , Quante M: Dclk1-expressing tuft cells: Critical modulators of the intestinal niche?. Am J Physiol Gastrointest Liver Physiol 2017 Jul:ajpgi 00073 02017.

Munera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM: Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell 2017 Jul, 21(1):51-64 e56.

Spence JR: Clocking the Pace of Organoid Research. Cell Mol Gastroenterol Hepatol 2017 Jul, 4(1):203-204.

Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ: Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell 2017 Jul, 21(1):78-90 e76.

McCracken KW, Wells JM : Mechanisms of embryonic stomach development. Semin Cell Dev Biol 2017 Jun, 66:36-42.

Chin AM, Hill DR, Aurora M, Spence JR : Morphogenesis and maturation of the embryonic and postnatal intestine. Semin Cell Dev Biol 2017 Jun, 66:81-93.

Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L : Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res 2017 May, 77(9):2512-2521.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC: Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature 2017 May, 545(7653):234-237.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature 2017 May, 545(7653):238-242.

Smith NR, Davies PS, Levin TG, Gallagher AC, Keene DR, Sengupta SK, Wieghard N, El Rassi E, Wong MH : Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis. Cell Mol Gastroenterol Hepatol 2017 May, 3(3):389-409.

Mahe MM, Brown NE, Poling HM, Helmrath MA : In Vivo Model of Small Intestine. Methods Mol Biol 2017 Apr, 1597:229-245.

Munera JO, Wells JM : Generation of Gastrointestinal Organoids from Human Pluripotent Stem Cells. Methods Mol Biol 2017 Apr, 1597:167-177.

Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ: Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med 2017 Apr, 23(4):450-460.

McCauley HA, Wells JM : Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development 2017 Mar, 144(6):958-962.

Rouch JD, Dunn JC : New insights and interventions for short bowel syndrome. Curr Pediatr Rep 2017 Mar, 5(1):1-5.

Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD , Spence JR : In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development 2017 Mar, 144(6):1045-1055.

Hill DR, Spence JR : Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface. Cell Mol Gastroenterol Hepatol 2017 Mar, 3(2):138-149.

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer 2017 Feb, 16(1):30.

Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M : The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol 2017 Feb, 79:291-312.

Hong SN, Dunn JC, Stelzner M, Martin MG : Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure. Stem Cells Transl Med 2017 Feb, 6(2):666-676.

Tong J, Tan S, Zou F, Yu J, Zhang L : FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. Oncogene 2017 Feb, 36(6):787-796.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM: Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med 2017 Jan, 23(1):49-59.

Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF: Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. Cell Mol Gastroenterol Hepatol 2017 Jan, 3(1):51-71.

Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC: Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell 2017 Jan, 31(1):21-34.

Czerwinski M, Spence JR: Hacking the Matrix. Cell Stem Cell 2017 Jan, 20(1):9-10.
Kulkarni S, Wang TC, Guha C : Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries. Curr Pathobiol Rep 2016 Dec, 4(4):221-230.

Aurora M, Spence JR : hPSC-derived lung and intestinal organoids as models of human fetal tissue. Dev Biol 2016 Dec, 420(2):230-238.

In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M : Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol 2016 Nov, 13(11):633-642.

Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR : A Dynamic WNT/beta-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. Stem Cell Reports 2016 Nov, 7(5):826-839.

Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J : Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest 2016 Nov, 126(11):4076-4087.

Chandrakesan P, May R, Weygant N, Qu D, Berry WL, Sureban SM, Ali N, Rao C, Huycke M, Bronze MS, Houchen CW: Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep 2016 Nov, 6:37667.

Saha S, Aranda E, Hayakawa Y, Bhanja P, Atay S, Brodin NP, Li J, Asfaha S, Liu L, Tailor Y, Zhang J, Godwin AK, Tome WA, Wang TC, Guha C, Pollard JW: Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. Nat Commun 2016 Oct, 7:13096.

Westphalen CB, Middelhoff M, Quante M, Wang TC : Epithelial Dclk1+ cells are not neural crest derived. Stem Cell Investig 2016 Oct, 3:60.

Sailaja BS, He XC, Li L : The regulatory niche of intestinal stem cells. J Physiol 2016 Sep, 594(17):4827-4836.

Mah AT, Yan KS, Kuo CJ : Wnt pathway regulation of intestinal stem cells. J Physiol 2016 Sep, 594(17):4837-4847.

Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L : Stem Cells and Regeneration in the Digestive System: Keystone Meeting. Gastroenterology 2016 Sep, 151(3):e6-9.

Tsai YH, Hill DR, Kumar N, Huang S, Chin AM, Dye BR, Nagy MS, Verzi MP , Spence JR : LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation. Cell Mol Gastroenterol Hepatol 2016 Sep, 2(5):648-662 e648.

Smith NR, Gallagher AC, Wong MH: Defining a stem cell hierarchy in the intestine: markers, caveats and controversies. J Physiol 2016 Sep, 594(17):4781-4790.

Henning SJ, von Furstenberg RJ. GI stem cells - new insights into roles in physiology and pathophysiology. J Physiol, 2016 Sep, 594(17): 4769-79. PMCID: 4847377.

Wang Y, Wang X, Flores ER, Yu J, Chang S: Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell 2016 Aug, 15(4):646-660.

Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA: Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep 2016 Aug, 16(8):2053-2060.

Lund PK, Verzi MP. Singling Out Intestinal Epithelial Stem Cells. Gastroenterology, 2016 Aug, 151(2): 228-31.

Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD: Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight 2016 Jul, 1(10).

Khalil HA, Lei NY, Brinkley G, Scott A, Wang J, Kar UK, Jabaji ZB, Lewis M, Martin MG, Dunn JC, Stelzner MG: A novel culture system for adult porcine intestinal crypts. Cell Tissue Res 2016 Jul, 365(1):123-134.

Scott A, Rouch JD, Jabaji Z, Khalil HA, Solorzano S, Lewis M, Martin MG, Stelzner MG, Dunn JC : Long-term renewable human intestinal epithelial stem cells as monolayers: A potential for clinical use. J Pediatr Surg 2016 Jun, 51(6):995-1000.

Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA : Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell 2016 Jun, 165(6):1389-1400.

Li X, Ootani A, Kuo C: An Air-Liquid Interface Culture System for 3D Organoid Culture of Diverse Primary Gastrointestinal Tissues. Methods Mol Biol 2016 Jun, 1422:33-40.

Neal JT, Kuo CJ : Organoids as Models for Neoplastic Transformation. Annu Rev Pathol 2016 May, 11:199-220.

Dedhia PH, Bertaux-Skeirik N, Zavros Y, Spence JR : Organoid Models of Human Gastrointestinal Development and Disease. Gastroenterology 2016 May, 150(5):1098-1112.

Chandrakesan P, Panneerselvam J, Qu D, Weygant N, May R, Bronze MS, Houchen CW : Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells. J Carcinog Mutagen 2016 Apr, 7(2).

Chen D, Yu J, Zhang L : Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta 2016 Apr, 1865(2):228-236.

Mah AT, Kuo CJ : Home Sweet Home: a Foxl1+ Mesenchymal Niche for Intestinal Stem Cells. Cell Mol Gastroenterol Hepatol 2016 Mar, 2(2):116-117.

Wells JM : Regenerative medicine in 2015: Generating and regenerating the digestive system. Nat Rev Gastroenterol Hepatol 2016 Feb, 13(2):65-66.

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem, 2016 Feb, 291(8): 3759-66. PMCID: 4759158.

Rouch JD, Scott A, Lei NY, Solorzano-Vargas RS, Wang J, Hanson EM, Kobayashi M, Lewis M, Stelzner MG, Dunn JC, Eckmann L, Martin MG: Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. PLoS One 2016 Jan, 11(1):e0148216.
Sailaja BS, He XC, Li L : Stem Cells Matter in Response to Fasting. Cell Rep 2015 Dec, 13(11):2325-2326.

Asfaha S : Intestinal stem cells and inflammation. Curr Opin Pharmacol 2015 Dec, 25:62-66.

Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK: Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res 2015 Nov, 13(11):1478-1486.

DiMarco RL, Dewi RE, Bernal G, Kuo C, Heilshorn SC: Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids. Biomater Sci 2015 Oct, 3(10):1376-1385.

Chandrakesan P, May R, Qu D, Weygant N, Taylor VE, Li JD, Ali N, Sureban SM, Qante M, Wang TC, Bronze MS, Houchen CW: Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal. Oncotarget 2015 Oct, 6(31):30876-30886.

Finkbeiner SR, Freeman JJ, Wieck MM, El-Nachef W, Altheim CH, Tsai YH, Huang S, Dyal R, White ES, Grikscheit TC, Teitelbaum DH, Spence JR: Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids. Biol Open 2015 Oct, 4(11):1462-1472.

Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, Sureban SM, An G, Schlosser MJ, Houchen CW : Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PLoS One 2015 Aug, 10(8):e0134212.

Huang JY, Sweeney EG, Sigal M, Zhang HC, Remington SJ, Cantrell MA, Kuo CJ , Guillemin K, Amieva MR: Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium. Cell Host Microbe 2015 Aug, 18(2):147-156.

Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW: Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury. PLoS One 2015 Aug, 10(8):e0135561.

Seiler KM, Schenhals EL, von Furstenberg RJ, Allena BK, Smith BJ, Scaria D, Bresler MN, Dekaney CM, Henning SJ: Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage. Cell Tissue Res 2015 Aug, 361(2):427-438.

Asfaha S, Hayakawa Y, Muley A, Stokes S, Graham TA, Ericksen RE, Westphalen CB, von Burstin J, Mastracci TL, Worthley DL, Guha C, Quante M, Rustgi AK, Wang TC: Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell Stem Cell 2015 Jun, 16(6):627-638.

Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR: Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports 2015 Jun.

Sinagoga KL, Wells JM : Generating human intestinal tissues from pluripotent stem cells to study development and disease. EMBO J 2015 May, 34(9):1149-1163.

Khalil HA, Lei NY, Nie W, Lewis MS, Stelzner MG, Martin MG, Dunn JC , Yoo J: Primary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy. PLoS One 2015 May, 10(5):e0127258.

Canani RB, Castaldo G, Bacchetta R, Martin MG, Goulet O: Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies. Nat Rev Gastroenterol Hepatol 2015 May, 12(5):293-302.

Goodell MA, Nguyen H, Shroyer N: Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol 2015 May, 16(5):299-309.

Hamilton KE, Crissey MA, Lynch JP, Rustgi AK: Culturing adult stem cells from mouse small intestinal crypts. Cold Spring Harb Protoc 2015 Apr, 2015(4):354-358.

Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD : Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep 2015 Apr, 11(1):33-42.

Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JC, Martin MG, Lagasse E, Zhang L, Yu J: Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. < i>Sci Rep 2015 Apr, 5:8566.

Wells JM : Developmental biology. Regional identity of gut stem cells--one gene to rule them all. Nat Rev Gastroenterol Hepatol 2015 Mar, 12(3):125-126.

McGrath PS, Wells JM : SnapShot: GI tract development. Cell 2015 Mar, 161(1):176-176 e171.

Gracz AD, Williamson IA, Roche KC, Johnston MJ, Wang F, Wang Y, Attayek PJ, Balowski J, Liu XF, Laurenza RJ, Gaynor LT, Sims CE, Galanko JA, Li L, Allbritton NL, Magness ST: A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis. Nat Cell Biol 2015 Mar, 17(3):340-349.

Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA : Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp 2015 Mar, (97).

Salahudeen AA, Kuo CJ : Toward recreating colon cancer in human organoids. Nat Med 2015 Mar, 21(3):215-216.

Cantrell MA, Kuo CJ : Organoid modeling for cancer precision medicine. Genome Med 2015 Mar, 7(1):32.

Yan KS, Kuo CJ : Ascl2 reinforces intestinal stem cell identity. Cell Stem Cell 2015 Feb, 16(2):105-106.

Nakagawa H, Whelan K, Lynch JP: Mechanisms of Barrett's oesophagus: intestinal differentiation, stem cells, and tissue models. Best Pract Res Clin Gastroenterol 2015 Feb, 29(1):3-16.

Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu WJ, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, Longaker MT: Identification and specification of the mouse skeletal stem cell. Cell 2015 Jan, 160(1-2):285-298.
McCracken KW, Cata EM, Crawford CM, Sinagoga KL, Schumacher M, Rockich BE, Tsai YH, Mayhew CN, Spence JR, Zavros Y, Wells JM: Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 2014 Dec, 516(7531):400-404.

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