ISCC Publications

Publications from ISCC Support (215)

This is a list of publications representing the work supported by funding from the ISCC program. The articles are ordered by year of publication. Authors names that are in bold represent past or present ISCC Investigators.
Dang LT, Miao Y, Ha A, Yuki K, Park K, Janda CY, Jude KM, Mohan K, Ha N, Vallon M, Yuan J, Vilches-Moure JG, Kuo CJ, Garcia KC, Baker D. Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat Struct Mol Biol, 2019 Jun, 26(6): 407-14. PMCID: 6582999.

Khalil HA, Hong SN, Rouch JD, Scott A, Cho Y, Wang J, Lewis MS, Martin MG, Dunn JCY, Stelzner MG. Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. PLoS One, 2019 Jun Epub, 14(5): e0216326. PMCID: 6544206.

Chen L, Toke NH, Luo S, Vasoya RP, Fullem RL, Parthasarathy A, Perekatt AO, Verzi MP. A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Nat Genet, 2019 May, 51(5): 777-85.

Holloway EM, Capeling MM, Spence JR. Biologically inspired approaches to enhance human organoid complexity. Development, Review, 2019 Apr Epub, 146(8). PMCID: 6503984.

Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF. Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer. Molecular Cancer Research, 2019 Mar, 17(3): 697-708.

Hayakawa Y, Tsuboi M, Asfaha S, Kinoshita H, Niikura R, Konishi M, Hata M, Oya Y, Kim W, Middelhoff M, Hikiba Y, Higashijima N, Ihara S, Ushiku T, Fukayama M, Tailor Y, Hirata Y, Guha C, Yan KS, Koike K, Wang TC. BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice. Gastroenterology, 2019 Mar, 156(4): 1066-81 e16. PMCID: 6409180.

Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell, 2019 Mar [Epub ahead of print].

Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP. The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development, 2019 Mar, 146(5). PMCID: 6432663.

Zwick RK, Ohlstein B, Klein OD. Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila. Am J Physiol Gastrointest Liver Physiol, 2019 Mar, 316(3): G313-G22.

Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR. Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids. Stem Cell Reports, 2019 Feb, 12(2): 381-94.

Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S.Atoh1(+) secretory progenitors possess renewal capacity independent of Lgr5(+) cells during colonic regeneration. EMBO J, 2019 Feb, 38(4). PMCID: 6376326.

Wang TC, Martin MG, Kuo CJ, Klein OD, Niland J. Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium. Am J Physiol Gastrointest Liver Physiol, 2019 Feb, 316(2): G247-G50.

Han X, Lee A, Huang S, Gao J, Spence JR, Owyang C. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes, 2019 Jan, 10(1): 59-76. PMCID: 6363076.

Hu D, Yan H, He XC, Li L. Recent advances in understanding intestinal stem cell regulation. F1000Res, 2019 Jan Epub, 8. PMCID: 6343229.

Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD. Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells. Cell Stem Cell, 2019 Jan, 24(1): 183-92 e8. PMCID: 6320295.

Schoenborn AA, von Furstenberg RJ, Valsaraj S, Hussain FS, Stein M, Shanahan MT, Henning SJ, Gulati AS. The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells. Gut Microbes, 2019 Jan, 10(1): 45-58. PMCID: 6363071.
Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, Schultz LM, Metzner TJ, Nadauld LD, Tseng YY, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Liao JC, Leppert JT, Sunwoo JB, Sabatti C, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ. Organoid Modeling of the Tumor Immune Microenvironment. Cell, 2018 Dec, 175(7): 1972-88 e16.

Banerjee KK, Saxena M, Kumar N, Chen L, Cavazza A, Toke NH, O'Neill NK, Madha S, Jadhav U, Verzi MP, Shivdasani RA. Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev, 2018 Nov, 32(21-22): 1430-42. PMCID: 6217732.

Rankin CR, Theodorou E, Man Law IK, Rowe L, Kokkotou E, Pekow J, Wang J, Martin MG, Pothoulakis C, Padua D. Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol, 2018 Nov, 315(5): G722-G33.

Cortez AR, Poling HM, Brown NE, Singh A, Mahe MM, Helmrath MA. Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site. Surgery, 2018 Oct, 164(4): 643-50.

Lee KK, McCauley HA, Broda TR, Kofron MJ, Wells JM, Hong CI. Human stomach-on-a-chip with luminal flow and peristaltic-like motility. Lab Chip, 2018 Oct, 18(20): 3079-85.

Lueschow SR, Stumphy J, Gong H, Kern SL, Elgin TG, Underwood MA, Kalanetra KM, Mills DA, Wong MH, Meyerholz DK, Good M, McElroy SJ. Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. PLoS One, 2018 Oct Epub, 13(10): e0204967. PMCID: 6166990

Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Cell Rep, 2018 Oct Epub, 25(2): 339-49 e9. PMCID: 6338448.

Weichselbaum L, Klein OD . The intestinal epithelial response to damage. Sci China Life Sci, Review, 2018 Oct, 61(10): 1205-11.

Cruz-Acuna R, Quiros M, Huang S, Siuda D, Spence JR, Nusrat A, Garcia AJ. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc, 2018 Sep, 13(9): 2102-19. Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc, 2018 Oct.

Samsa LA, Williamson IA, Magness ST. Quantitative Analysis of Intestinal Stem Cell Dynamics Using Microfabricated Cell Culture Arrays. Methods Mol Biol, 2018 Sep, 1842: 139-66.

Santos AJM, Lo YH, Mah AT, Kuo CJ. The Intestinal Stem Cell Niche: Homeostasis and Adaptations. Trends Cell Biol, 2018 Dec, 28(12): 1062-78. PMCID: 6338454.

Bankaitis ED, Ha A, Kuo CJ, Magness ST . Reserve Stem Cells in Intestinal Homeostasis and Injury. Gastroenterology, Review, 2018 Aug.

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature 2018 Jul, 559(7712):109-113. PMCID: 6042247.

Srivillibhuthur M, Warder BN, Toke NH, Shah PP, Feng Q, Gao N, Bonder EM, Verzi MP: TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol 2018 Jul, 439(2):92-101. PMCID: 5978755.

Dubrovsky G, Dunn JCY . Mechanisms for intestinal regeneration. Curr Opin Pediatr, Review, 2018 Jun, 30(3): 424-9.

McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD: Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife 2018 Jun Epub, 7. PMCID: 6023609.

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM. Mechanically induced development and maturation of human intestinal organoids in vivo. Nat Biomed Eng, 2018 Jun, 2(6): 429-42. PMCID: 6108544.

Smith NR, Swain JR, Davies PS, Gallagher AC, Parappilly MS, Beach CZ, Streeter PR, Williamson IA, Magness ST, Wong MH. Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations. Cell Mol Gastroenterol Hepatol, 2018 Jun, 6(1): 79-96. PMCID: 6008251.

Takebe T, Wells JM, Helmrath MA, Zorn AM. Organoid Center Strategies for Accelerating Clinical Translation. Cell Stem Cell, 2018 Jun, 22(6): 806-9.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martin MG, Pedi CC: Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 2018 Jun, 154(8):2045-2059 e2046. PMCID: 6044208.

Chatterji P, Rustgi AK . RNA Binding Proteins in Intestinal Epithelial Biology and Colorectal Cancer. Trends Mol Med, Review, 2018 May, 24(5): 490-506. PMCID: 5927824.

Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L: Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene 2018 Aug, 37(33): 4599-610. PMCID: 6195818.

Wang Q, Wang K, Solorzano-Vargas RS, Lin PY, Walthers CM, Thomas AL, Martin MG, Dunn JCY: Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractions. PLoS One 2018 May Epub, 13(5):e0195315. PMCID: 5931477.

Wells JM, Watt FM. Diverse mechanisms for endogenous regeneration and repair in mammalian organs. Nature, 2018 May, 557(7705): 322-8.

Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L: PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci USA 2018 Apr, 115(15):3930-3935. PMCID: 5899441.

Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L: Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta 2018 Apr, 1869(2):138-148. PMCID: 5955808.

Kuo CJ, Curtis C. Organoids reveal cancer dynamics. Nature, 2018 Apr, 556(7702): 441-2.

Ramani S, Crawford SE, Blutt SE, Estes MK. Human organoid cultures: transformative new tools for human virus studies. Curr Opin Virol, Review, 2018 Apr, 29: 79-86. PMCID: 5944856.

Spence JR: Taming the Wild West of Organoids, Enteroids, and Mini-Guts. Cell Mol Gastroenterol Hepatol 2018 Apr, 5(2):159-160. PMCID: 5904044.

Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK: Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol 2018 Mar Epub, 5(3): 241-51. PMCID: 5904028.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA. Identification, isolation, and characterization of human LGR5-positive colon adenoma cells. Development, 2018 Feb, 145(6). PMCID: 5897593.

Rankin SA, McCracken KW, Luedeke DM, Han L, Wells JM, Shannon JM, Zorn AM: Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis. Dev Biol 2018 Feb, 434(1):121-132. PMCID: 5785443.

Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martin MG, Alrefai WA, Ford DA, Tontonoz P: Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 2018 Feb Epub, 22(2):206-220 e4. PMCID: 5807072.

Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA. Beta-catenin cleavage enhances transcriptional activation. Sci Rep, 2018 Jan, 8(1): 671. PMCID: 5766502.

Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD , Shroyer NF , Donowitz M , Estes MK: Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep 2018 Jan, 22(4):1003-1015. PMCID: 5798462.
Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martin MG, Allenspach K: Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research. AAPS J 2017 Dec, 20(1):17.

Tong K, Pellon-Cardenas O, Sirihorachai VR, Warder BN, Kothari OA, Perekatt AO, Fokas EE, Fullem RL, Zhou A, Thackray JK, Tran H, Zhang L, Xing J, Verzi MP: Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. Cell Rep 2017 Dec, 21(13):3833-3845.

Cruz-Acuna R, Quiros M, Farkas AE, Dedhia PH, Huang S, Siuda D, Garcia-Hernandez V, Miller AJ, Spence JR, Nusrat A, Garcia AJ: Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat Cell Biol 2017 Nov, 19(11):1326-1335.

Hill DR, Huang S, Nagy MS, Yadagiri VK, Fields C, Mukherjee D, Bons B, Dedhia PH, Chin AM, Tsai YH, Thodla S, Schmidt TM, Walk S, Young VB, Spence JR: Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. Elife 2017 Nov, 6.

Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK . Gastrointestinal microphysiological systems. Exp Biol Med (Maywood), Review, 2017 Oct, 242(16): 1633-42. PMCID: 5661769.

Yousefi M, Li L, Lengner CJ: Hierarchy and Plasticity in the Intestinal Stem Cell Compartment. Trends Cell Biol 2017 Oct, 27(10):753-764.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A: Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.J Clin Invest 2017 Sep, 127(9):3510-3520.

Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L : FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther 2017 Sep, 16(9):1979-1988.

Moorefield EC, Andres SF, Blue RE, Van Landeghem L, Mah AT, Santoro MA, Ding S: Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells. Aging (Albany NY) 2017 Aug, 9(8):1898-1915.

Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA : Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell 2017 Jul, 21(1):65-77 e65.

Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC , Quante M: Dclk1-expressing tuft cells: Critical modulators of the intestinal niche?. Am J Physiol Gastrointest Liver Physiol 2017 Jul:ajpgi 00073 02017.

Munera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM: Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell 2017 Jul, 21(1):51-64 e56.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Jr., Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA: A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology 2017 Jul, 153(1):e6-e13.

Spence JR: Clocking the Pace of Organoid Research. Cell Mol Gastroenterol Hepatol 2017 Jul, 4(1):203-204.

Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ: Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell 2017 Jul, 21(1):78-90 e76.

Chin AM, Hill DR, Aurora M, Spence JR : Morphogenesis and maturation of the embryonic and postnatal intestine. Semin Cell Dev Biol 2017 Jun, 66:81-93.

Kim GA, Spence JR , Takayama S. Bioengineering for intestinal organoid cultures. Curr Opin Biotechnol, Review, 2017 Jun, 47: 51-8.

McCracken KW, Wells JM : Mechanisms of embryonic stomach development. Semin Cell Dev Biol 2017 Jun, 66:36-42.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC: Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature 2017 May, 545(7653):234-237.

Smith NR, Davies PS, Levin TG, Gallagher AC, Keene DR, Sengupta SK, Wieghard N, El Rassi E, Wong MH : Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis. Cell Mol Gastroenterol Hepatol 2017 May, 3(3):389-409.

Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L : Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res 2017 May, 77(9):2512-2521.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature 2017 May, 545(7653):238-242.

Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ: Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med 2017 Apr, 23(4):450-460.

Mahe MM, Brown NE, Poling HM, Helmrath MA : In Vivo Model of Small Intestine. Methods Mol Biol 2017 Apr, 1597:229-245. Erratum to: In Vivo Model of Small Intestine. Methods Mol Biol, 2017 Jul Epub, 1597: E1.

Munera JO, Wells JM : Generation of Gastrointestinal Organoids from Human Pluripotent Stem Cells. Methods Mol Biol 2017 Apr, 1597:167-177.

Hill DR, Spence JR : Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface. Cell Mol Gastroenterol Hepatol 2017 Mar, 3(2):138-149.

McCauley HA, Wells JM : Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development 2017 Mar, 144(6):958-962.

Rouch JD, Dunn JC : New insights and interventions for short bowel syndrome. Curr Pediatr Rep 2017 Mar, 5(1):1-5.

Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD , Spence JR : In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development 2017 Mar, 144(6):1045-1055.

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer 2017 Feb, 16(1):30.

Hong SN, Dunn JC, Stelzner M, Martin MG : Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure. Stem Cells Transl Med 2017 Feb, 6(2):666-676.

Tong J, Tan S, Zou F, Yu J, Zhang L : FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. Oncogene 2017 Feb, 36(6):787-796.

Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M : The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol 2017 Feb, 79:291-312.

Czerwinski M, Spence JR: Hacking the Matrix. Cell Stem Cell 2017 Jan, 20(1):9-10.

Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC: Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell 2017 Jan, 31(1):21-34.

Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF: Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. Cell Mol Gastroenterol Hepatol 2017 Jan, 3(1):51-71.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM: Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med 2017 Jan, 23(1):49-59.
Aurora M, Spence JR : hPSC-derived lung and intestinal organoids as models of human fetal tissue. Dev Biol 2016 Dec, 420(2):230-238.

Kulkarni S, Wang TC, Guha C : Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries. Curr Pathobiol Rep 2016 Dec, 4(4):221-230.

Chandrakesan P, May R, Weygant N, Qu D, Berry WL, Sureban SM, Ali N, Rao C, Huycke M, Bronze MS, Houchen CW: Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep 2016 Nov, 6:37667.

Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR : A Dynamic WNT/beta-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. Stem Cell Reports 2016 Nov, 7(5):826-839.

In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M : Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol 2016 Nov, 13(11):633-642.

Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J : Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest 2016 Nov, 126(11):4076-4087.

Saha S, Aranda E, Hayakawa Y, Bhanja P, Atay S, Brodin NP, Li J, Asfaha S, Liu L, Tailor Y, Zhang J, Godwin AK, Tome WA, Wang TC, Guha C, Pollard JW: Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. Nat Commun 2016 Oct, 7:13096.

Westphalen CB, Middelhoff M, Quante M, Wang TC : Epithelial Dclk1+ cells are not neural crest derived. Stem Cell Investig 2016 Oct, 3:60.

Henning SJ, von Furstenberg RJ. GI stem cells - new insights into roles in physiology and pathophysiology. J Physiol, 2016 Sep, 594(17): 4769-79. PMCID: 4847377.

Mah AT, Yan KS, Kuo CJ : Wnt pathway regulation of intestinal stem cells. J Physiol 2016 Sep, 594(17):4837-4847.

Sailaja BS, He XC, Li L : The regulatory niche of intestinal stem cells. J Physiol 2016 Sep, 594(17):4827-4836.

Smith NR, Gallagher AC, Wong MH: Defining a stem cell hierarchy in the intestine: markers, caveats and controversies. J Physiol 2016 Sep, 594(17):4781-4790.

Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L : Stem Cells and Regeneration in the Digestive System: Keystone Meeting. Gastroenterology 2016 Sep, 151(3):e6-9.

Tsai YH, Hill DR, Kumar N, Huang S, Chin AM, Dye BR, Nagy MS, Verzi MP , Spence JR : LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation. Cell Mol Gastroenterol Hepatol 2016 Sep, 2(5):648-662 e648.

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